Detalhe da pesquisa
1.
Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Proc Natl Acad Sci U S A
; 120(18): e2216342120, 2023 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37098070
2.
Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Bioorg Med Chem Lett
; 96: 129492, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37778428
3.
GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine.
Mol Pharmacol
; 88(5): 911-25, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26349500
4.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem
; 66(4): 2877-2892, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757100
5.
5-(2'-Pyridyl)-2-aminothiazoles: alkyl amino sulfonamides and sulfamides as potent NPY(5) antagonists.
Bioorg Med Chem Lett
; 21(21): 6500-4, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21924902
6.
Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.
Bioorg Med Chem Lett
; 21(7): 2092-7, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353551
7.
Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
J Pharmacol Exp Ther
; 332(3): 764-75, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19996299
8.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett
; 11(10): 2002-2009, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062185
9.
Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Bioorg Med Chem Lett
; 19(16): 4647-51, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608418
10.
Pharmacology of JNJ-28583113: A novel TRPM2 antagonist.
Eur J Pharmacol
; 853: 299-307, 2019 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30965058
11.
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors.
Bioorg Med Chem
; 16(3): 1359-75, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17983756
12.
Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.
ACS Med Chem Lett
; 6(9): 1015-8, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396690
13.
Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
Bioorg Med Chem Lett
; 16(15): 3950-4, 2006 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730981