Detalhe da pesquisa
1.
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles.
Int J Mol Sci
; 23(21)2022 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36361896
2.
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Neurobiol Dis
; 129: 217-233, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30928644
3.
Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure.
Bioorg Med Chem
; 26(12): 3296-3307, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29753566
4.
New phenylaniline derivatives as modulators of amyloid protein precursor metabolism.
Bioorg Med Chem
; 26(8): 2151-2164, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29559198
5.
High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists.
Eur J Med Chem
; 241: 114620, 2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35933788
6.
Design, Synthesis and Evaluation of a Series of 1,5-Diaryl-1,2,3-triazole-4-carbohydrazones as Inhibitors of the YAP-TAZ/TEAD Complex.
ChemMedChem
; 16(18): 2823-2844, 2021 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032019
7.
Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors.
Eur J Med Chem
; 226: 113835, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34509860
8.
Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-ß Precursor Protein Derived Fragments Processing.
Front Cell Neurosci
; 12: 435, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30524243
9.
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect ß-secretase inhibitors.
Eur J Med Chem
; 159: 104-125, 2018 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268822
10.
Toward the Discovery of a Novel Class of YAPâ»TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAPâ»TEAD Proteinâ»Protein Interface.
Cancers (Basel)
; 10(5)2018 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29738494
11.
Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway.
ChemMedChem
; 12(12): 954-961, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334506