Postoperative fevers in pediatric solid tumor patients: how should they be managed?

UNLABELLED: It is unclear how aggressively postoperative fevers should be managed in immunosuppressed pediatric oncology patients after major surgery. Little data exists on this subject. Therefore, a retrospective study of patients treated at our center was undertaken to examine this. PURPOSES: (1) to describe the prevalence of fever and infection in postoperative pediatric solid tumor patients undergoing primary tumor resection, (2) to examine the risk factors that contribute to the development of postoperative infections, and (3) to describe the variation in practice in managing fevers. METHODS: Chart reviews were performed on patients diagnosed with a spectrum of tumor types from January 2000 to October 2005 who received preoperative chemotherapy, followed by tumor resection. RESULTS: Ninety-eight children met inclusion criteria and 73 (74%) developed fevers postoperatively; 14% of these had documented infections and 1 patient died from sepsis. Factors associated with increased risk of infection were a diagnosis of neuroblastoma (P=0.015), and surgery longer than 8 hours (P=0.059). The investigation and management of postoperative fevers varied in these patients. CONCLUSIONS: Postoperative fevers may be indicative of severe infection. We suggest that a standardized approach to the management of these patients, including prompt physical assessment, clinical investigations, and empiric antibiotic consideration is vital to minimize complications.

Loop versus divided colostomy for the management of anorectal malformations.

PURPOSE: The purpose of this study was to compare the clinical outcomes of loop and divided colostomies in patients with anorectal malformations (ARM). METHODS: We performed a retrospective cohort study reviewing the medical records of all patients with ARM managed with diverting colostomies between 2000 and 2010 at our institution. Independent variables and outcomes of stoma complications were analyzed by parametric measures and logistic regression. RESULTS: One hundred forty-four patients managed with a colostomy for ARM were evaluated (37.5% females, 50.7% loop, 49.3% divided). The incidence of patients with loop and divided colostomies who developed stoma-related complications was 31.5 and 15.5%, respectively (p=0.031). The incidence of prolapse was 17.8 and 2.8%, respectively (p=0.005). Multivariable-logistic regression controlling for other significant independent variables found loop colostomies to be positively associated with the development of a stoma complication (OR 3.13, 95%CI (1.09, 8.96), p=0.033). When individual complications were evaluated, it was only stoma prolapse that was more likely in patients with loop colostomies (OR 8.75, 95%CI (1.74, 44.16), p=0.009). CONCLUSION: Because of the higher incidence of prolapse, loop colostomies were found to be associated with a higher total incidence of complications than divided stomas. The development of other complications, including urinary tract infections (UTIs) and megarectum, were independent of the type of colostomy performed.

Association between parental anxiety and compliance with preoperative requirements for pediatric outpatient surgery.

PURPOSE: The purpose of this study was to determine if parental anxiety interferes with the ability to follow preoperative requirements. METHOD: In a single center observational study of parents of children admitted to a same-day surgical unit at a tertiary pediatric hospital, parental preoperative anxiety was measured by the State-Trait Anxiety Inventory (STAI) questionnaire. Anxiety was correlated to a four points assessment of adherence with the following preoperative requirements: dietary restrictions, timely arrival at the hospital, arrival at the assigned room, and completion of required medical forms, because those requirements are the greatest external contributors to surgical cancellation according to hospital statistics. RESULTS: A total of 203 families completed the study. The average STAI score on the day of surgery was 38+/-12 (population average, 36+/-11). Only 130 families (66%) complied with all four preoperative requirements. A higher level of anxiety was significantly associated with lower probability of compliance (odds ratio, 0.88; 95% confidence interval, 0.78-1.00, P=05). In univariate models, factors associated with higher STAI scores included younger parent age, younger children, only child, child's first surgery, and no medical consultation between surgical assessment and surgery. DISCUSSION: Parental anxiety could be associated with a lower likelihood of parents following preoperative requirements and could contribute to increased likelihood of surgical cancellation.

Minimizing complications related to fever in the postoperative pediatric oncology patient.

Fever is a common postoperative complication that is generally thought to be a benign, self-limiting event. However, for pediatric oncology patients who are often immunocompromised, a postoperative fever may indicate an infection, which can lead to significant complications if not treated promptly. A physical examination, which is an established cost-effective method to rule out infections in the general surgical population, may not be sufficient for oncology patients because clinical symptoms may be atypical or absent in immunocompromised hosts. Although a full septic workup may be unnecessary, additional investigations such as blood cultures may be warranted, and antibiotic therapy should be considered for some or all febrile postoperative cancer patients. No standardized approach to fever management in postoperative oncology patients currently exists, which can present a challenge for those who care for these patients. In the absence of such established practice standards, this article outlines some of the considerations that may be vital in minimizing complications related to fever in the postoperative pediatric oncology patient.