Detalhe da pesquisa
1.
Hyperinsulinemia, an overlooked clue and potential way forward in metabolic dysfunction-associated steatotic liver disease.
Hepatology
; 2023 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051957
2.
Novel insulin sensitizer MSDC-0602K improves insulinemia and fatty liver disease in mice, alone and in combination with liraglutide.
J Biol Chem
; 296: 100807, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34022222
3.
Suboptimal reliability of liver biopsy evaluation has implications for randomized clinical trials.
J Hepatol
; 73(6): 1322-1332, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32610115
4.
Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study.
J Hepatol
; 72(4): 613-626, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31697972
5.
Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis.
Hepatology
; 65(5): 1543-1556, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28027586
6.
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.
Exp Physiol
; 102(8): 985-999, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28597936
7.
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier.
Proc Natl Acad Sci U S A
; 110(14): 5422-7, 2013 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23513224
9.
Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione.
J Biol Chem
; 287(28): 23537-48, 2012 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22621923
10.
PPARγ-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development.
Bioorg Med Chem
; 26(22): 5870-5884, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30429097
11.
Insulin sensitizers in 2023: lessons learned and new avenues for investigation.
Expert Opin Investig Drugs
; 32(9): 803-811, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37755339
12.
Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism.
Mol Metab
; 70: 101694, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36801448
13.
A DUAL MTOR/NAD+ ACTING GEROTHERAPY.
bioRxiv
; 2023 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36711589
14.
Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.
Sci Immunol
; 8(82): eadf0348, 2023 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36821695
15.
The metabolic syndrome, thiazolidinediones, and implications for intersection of chronic and inflammatory disease.
Mol Metab
; 55: 101409, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34863942
16.
Metabolic Mechanisms Connecting Alzheimer's and Parkinson's Diseases: Potential Avenues for Novel Therapeutic Approaches.
Front Mol Biosci
; 9: 929328, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35782864
17.
Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson's Disease.
Mol Neurobiol
; 59(10): 6170-6182, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-35895232
18.
NASH (nonalcoholic steatohepatitis), diabetes, and macrovascular disease: multiple chronic conditions and a potential treatment at the metabolic root.
Expert Opin Investig Drugs
; 29(2): 191-196, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31928475
19.
Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue.
Nutrients
; 12(12)2020 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33291653
20.
Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits.
Free Neuropathol
; 12020.
Artigo
em Inglês
| MEDLINE | ID: mdl-35224554