Detalhe da pesquisa
1.
First-in-human clinical trial to assess pharmacokinetics, pharmacodynamics, safety, and tolerability of iscalimab, an anti-CD40 monoclonal antibody.
Am J Transplant
; 20(2): 463-473, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31647605
2.
A randomized, placebo-controlled trial of canakinumab in patients with peripheral artery disease.
Vasc Med
; 24(5): 414-421, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31277561
3.
Prevalence of rheumatic heart disease in Zambian school children.
BMC Cardiovasc Disord
; 18(1): 135, 2018 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29969998
4.
Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease.
BMC Infect Dis
; 17(1): 473, 2017 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28683722
5.
Long-term effects of secukinumab on MRI findings in relation to clinical efficacy in subjects with active ankylosing spondylitis: an observational study.
Ann Rheum Dis
; 75(2): 408-12, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26248638
6.
A 24-month open-label study of canakinumab in neonatal-onset multisystem inflammatory disease.
Ann Rheum Dis
; 74(9): 1714-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24906637
7.
LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing.
Nucleic Acids Res
; 40(5): 1904-15, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22067449
8.
Chromatin disruption in the promoter of bovine leukemia virus during transcriptional activation.
Nucleic Acids Res
; 39(22): 9559-73, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21890901
9.
The chromatin remodelling protein LSH/HELLS regulates the amount and distribution of DNA hydroxymethylation in the genome.
Epigenetics
; 17(4): 422-443, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33960278
10.
DNA cytosine methylation in the bovine leukemia virus promoter is associated with latency in a lymphoma-derived B-cell line: potential involvement of direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator/activation transcription factor binding.
J Biol Chem
; 285(25): 19434-49, 2010 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413592
11.
A Multicentre, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy, Safety, and Tolerability of the S1P Receptor Agonist KRP203 in Patients with Moderately Active Refractory Ulcerative Colitis.
Inflamm Intest Dis
; 5(4): 180-190, 2020 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-33313070
12.
A Novel Anti-CD40 Monoclonal Antibody, Iscalimab, for Control of Graves Hyperthyroidism-A Proof-of-Concept Trial.
J Clin Endocrinol Metab
; 105(3)2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31512728
13.
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.
Retrovirology
; 6: 111, 2009 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19961595
14.
How Often Do Safety Signals Occur by Chance in First-in-Human Trials?
Clin Transl Sci
; 11(5): 471-476, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29702733
15.
Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.
Sci Rep
; 6: 24090, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27076174
16.
5-hydroxymethylcytosine marks promoters in colon that resist DNA hypermethylation in cancer.
Genome Biol
; 16: 69, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25853800
17.
HIV-1 chromatin, transcription, and the regulatory protein Tat.
Methods Mol Biol
; 1087: 85-101, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24158816
18.
Bioequivalence of canakinumab liquid pre-filled syringe and reconstituted lyophilized formulations following 150 mg subcutaneous administration: a randomized study in healthy subjects.
Clin Drug Investig
; 33(11): 801-8, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24030571
19.
Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4(+) T cells from HIV-1-infected HAART-treated patients.
AIDS
; 26(12): 1473-82, 2012 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22555163
20.
The AP-1 binding sites located in the pol gene intragenic regulatory region of HIV-1 are important for viral replication.
PLoS One
; 6(4): e19084, 2011 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21526160