Multi-toric optical element to compensate ocular astigmatism with increased tolerance under rotation.

A new, to the best of our knowledge, optical element designed to compensate regular astigmatism while exhibiting increased tolerance to rotational misalignment is introduced. The element incorporates an optical design based on concentric annular regions with slightly different cylindrical axis angular positions. To assess visual quality performance as a function of rotation, retinal image simulation and clinical assessments with an adaptive optics visual simulator were carried out. The results demonstrate the superior performance of the newly proposed element in the presence of rotational errors when compared to traditional solutions.

Mancha3D Code: Multipurpose Advanced Nonideal MHD Code for High-Resolution Simulations in Astrophysics.

The Mancha3D code is a versatile tool for numerical simulations of magnetohydrodynamic (MHD) processes in solar/stellar atmospheres. The code includes nonideal physics derived from plasma partial ionization, a realistic equation of state and radiative transfer, which allows performing high-quality realistic simulations of magnetoconvection, as well as idealized simulations of particular processes, such as wave propagation, instabilities or energetic events. The paper summarizes the equations and methods used in the Mancha3D (Multifluid (-purpose -physics -dimensional) Advanced Non-ideal MHD Code for High resolution simulations in Astrophysics 3D) code. It also describes its numerical stability and parallel performance and efficiency. The code is based on a finite difference discretization and a memory-saving Runge-Kutta (RK) scheme. It handles nonideal effects through super-time-stepping and Hall diffusion schemes, and takes into account thermal conduction by solving an additional hyperbolic equation for the heat flux. The code is easily configurable to perform different kinds of simulations. Several examples of the code usage are given. It is demonstrated that splitting variables into equilibrium and perturbation parts is essential for simulations of wave propagation in a static background. A perfectly matched layer (PML) boundary condition built into the code greatly facilitates a nonreflective open boundary implementation. Spatial filtering is an important numerical remedy to eliminate grid-size perturbations enhancing the code stability. Parallel performance analysis reveals that the code is strongly memory bound, which is a natural consequence of the numerical techniques used, such as split variables and PML boundary conditions. Both strong and weak scalings show adequate performance up to several thousands of processors (CPUs).

Holographic Sensor Based on Bayfol HX200 Commercial Photopolymer for Ethanol and Acetic Acid Detection.

This paper presents a holographic sensor based on reflection holograms recorded in the commercial photopolymer Bayfol® HX 200. The recording geometry and index modulation of the hologram were optimised to improve accuracy for this specific application. The sensor was subjected to tests using various analytes, and it exhibited sensitivity to acetic acid and ethanol. The measurements revealed a correlation between the concentration of the analyte in contact with the sensor's surface and the resulting wavelength shift of the diffracted light. The minimum detectable concentrations were determined to be above 0.09 mol/dm3 for acetic acid and 5% (v/v) for ethanol. Notably, the sensors demonstrated a rapid response time. Given that ethanol serves as a base for alcoholic beverages, and acetic acid is commonly found in commercial vinegar, these sensors hold promise for applications in food quality control.

Polarimetric characterization of segmented mirrors.

We study the impact of the loss of axial symmetry around the optical axis on the polarimetric properties of a telescope with a segmented primary mirror when each segment is present in a different aging stage. The different oxidation stage of each segment as it is substituted in time leads to nonnegligible cross-talk terms. This effect is wavelength dependent, and it is mainly determined by the properties of the reflecting material. For an aluminum coating, the worst polarimetric behavior due to oxidation is found for the blue part of the visible. Contrarily, dust-as modeled in this work-does not significantly change the polarimetric behavior of the optical system. Depending on the telescope, there might be segment substitution sequences that strongly attenuate this instrumental polarization.

Influence of ambipolar and Hall effects on vorticity in three-dimensional simulations of magneto-convection.

This paper presents the results of the analysis of three-dimensional simulations of solar magneto-convection that include the joint action of the ambipolar diffusion and the Hall effect. Three simulation runs are compared: one including both ambipolar diffusion and the Hall effect; one including only ambipolar diffusion and one without any of these two effects. The magnetic field is amplified from initial field to saturation level by the action of turbulent local dynamo. In each of these cases, we study 2 h of simulated solar time after the local dynamo reaches the saturation regime. We analyse the power spectra of vorticity, of magnetic field fluctuations and of the different components of the magnetic Poynting flux responsible for the transport of vertical or horizontal perturbations. Our preliminary results show that the ambipolar diffusion produces a strong reduction of vorticity in the upper chromospheric layers and that it dissipates the vortical perturbations converting them into thermal energy. The Hall effect acts in the opposite way, strongly enhancing the vorticity. When the Hall effect is included, the magnetic field in the simulations becomes, on average, more vertical and long-lived flux tube-like structures are produced. We trace a single magnetic structure to study its evolution pattern and the magnetic field intensification, and their possible relation to the Hall effect. This article is part of the Theo Murphy meeting issue 'High-resolution wave dynamics in the lower solar atmosphere'.

Stacked volume holographic gratings for extending the operational wavelength range in LED and solar applications.

A novel stacking procedure is presented for volume phase holographic gratings (VPHGs) recorded in photopolymer material using Corning Willow Glass as a flexible substrate in order to achieve broader angular and spectral selectivity in a diffractive device with high efficiency for solar and LED applications. For the first time to our knowledge, we have shown a device designed for use with a white LED that has the same input and output angles and high efficiency when illuminated by different wavelengths. In this paper, two VPHGs were designed, experimentally recorded, and tested when illuminated at normal incidence. The experimental approach is based on stacking two individual gratings in which the spatial frequency and slant have been tailored to the target wavelength and using real-time on-Bragg monitoring of the gratings in order to control the recorded refractive index modulation, thereby optimizing each grating efficiency for its design wavelength. Lamination of the two gratings together was enabled by using a flexible glass substrate (Corning Willow Glass). Recording conditions were studied in order to minimize the change in diffraction efficiency and peak diffraction angle during lamination and bleaching. The final fabricated stacked device was illuminated by a white light source, and its output was spectrally analyzed. Compared to a single grating, the stacked device demonstrated a twofold increase in angular and wavelength range. The angular and wavelength selectivity curves are in good agreement with the theoretical prediction for this design. This approach could be used to fabricate stacked lenses for white light LED or solar applications.

Repeatability and Reproducibility of Virtual Subjective Refraction.

PURPOSE: To establish the repeatability and reproducibility of a virtual refraction process using simulated retinal images. METHODS: With simulation software, aberrated images corresponding with each step of the refraction process were calculated following the typical protocol of conventional subjective refraction. Fifty external examiners judged simulated retinal images until the best sphero-cylindrical refraction and the best visual acuity were achieved starting from the aberrometry data of three patients. Data analyses were performed to assess repeatability and reproducibility of the virtual refraction as a function of pupil size and aberrometric profile of different patients. RESULTS: SD values achieved in three components of refraction (M, J0, and J45) are lower than 0.25D in repeatability analysis. Regarding reproducibility, we found SD values lower than 0.25D in the most cases. When the results of virtual refraction with different pupil diameters (4 and 6 mm) were compared, the mean of differences (MoD) obtained were not clinically significant (less than 0.25D). Only one of the aberrometry profiles with high uncorrected astigmatism shows poor results for the M component in reproducibility and pupil size dependence analysis. In all cases, vision achieved was better than 0 logMAR. A comparison between the compensation obtained with virtual and conventional subjective refraction was made as an example of this application, showing good quality retinal images in both processes. CONCLUSIONS: The present study shows that virtual refraction has similar levels of precision as conventional subjective refraction. Moreover, virtual refraction has also shown that when high low order astigmatism is present, the refraction result is less precise and highly dependent on pupil size.

Dislocations in magnetohydrodynamic waves in a stellar atmosphere.

We describe the presence of wave front dislocations in magnetohydrodynamic waves in stratified stellar atmospheres. Scalar dislocations such as edges and vortices can appear in Alfvén waves, as well as in general magnetoacoustic waves. We detect those dislocations in observations of magnetohydrodynamic waves in sunspots in the solar chromosphere. Through the measured charge of all the dislocations observed, we can give for the first time estimates of the modal contribution in the waves propagating along magnetic fields in solar sunspots.

Enhancement of filamentation postcompression by astigmatic focusing.

The energy scaling up of pulse postcompression is still an open issue. In this work we analyze the use of astigmatic focusing to improve the output pulses in a filamentation based postcompression setup. Unlike spherical conditions, astigmatic focusing enhances the output energy and the spectral broadening of the filament. This is due to the increase of critical power, allowing a considerable improvement of the postcompression energy and stability in a simple way. We demonstrated compression from FWHM 100 fs, 10 nm, 3 mJ input pulses to 13 fs, 142 nm, near 1 mJ pulses.

Three-dimensional magnetic field topology in a region of solar coronal heating.

Flares and X-ray jets on the Sun arise in active regions where magnetic flux emerges from the solar interior amd interacts with the ambient magnetic field. The interactions are believed to occur in electric current sheets separating regions of opposite magnetic polarity. The current sheets located in the corona or upper chromosphere have long been thought to act as an important source of coronal heating, requiring their location in the corona or upper chromosphere. The dynamics and energetics of these sheets are governed by a complex magnetic field structure that, until now, has been difficult to measure. Here we report the determination of the full magnetic vector in an interaction region near the base of the solar corona. The observations reveal two magnetic features that characterize young active regions on the Sun: a set of rising magnetic loops and a tangential discontinuity of the magnetic field direction, the latter being the observational signature of an electric current sheet. This provides strong support for coronal heating models based on the dissipation of magnetic energy at current sheets.

Characterization of transmission volume holographic gratings recorded in Slavich PFG04 dichromated gelatin plates.

We characterize Slavich PFG-04 dichromated gelatin plates to make transmission volume holographic elements recorded with a 532 nm laser source, obtaining high efficiency gratings with a high signal to noise ratio. The linear dynamic range of the material is studied by measuring the efficiency of multiplexed gratings. Results obtained are applied to the recording of holographic elements with high efficiency when they are illuminated with a 800 nm light source.

Retinal Image Simulation of Subjective Refraction Techniques.

Refraction techniques make it possible to determine the most appropriate sphero-cylindrical lens prescription to achieve the best possible visual quality. Among these techniques, subjective refraction (i.e., patient's response-guided refraction) is the most commonly used approach. In this context, this paper's main goal is to present a simulation software that implements in a virtual manner various subjective-refraction techniques--including Jackson's Cross-Cylinder test (JCC)--relying all on the observation of computer-generated retinal images. This software has also been used to evaluate visual quality when the JCC test is performed in multifocal-contact-lens wearers. The results reveal this software's usefulness to simulate the retinal image quality that a particular visual compensation provides. Moreover, it can help to gain a deeper insight and to improve existing refraction techniques and it can be used for simulated training.

Endothelin mediation of insulin and glucose-induced changes in vascular contractility.

Although the prevalence of hypertension in diabetic patients is high and many factors participate, hyperinsulinemia cannot be discarded as a contributing factor. Insulin could act directly on smooth muscle altering intracellular calcium levels that mediate contraction and glucose transport or could induce the secretion of endothelin by the endothelial cells lining the vessels. The aim of the present report was to study the effect of different glucose and insulin concentrations on rat vascular smooth-muscle contractile characteristics and to determine whether insulin effects are mediated by endothelin. Femoral arteries obtained from Wistar rats were placed in an in vitro chamber and superfused with different glucose and/or insulin solutions. The contractile response to KCl 80 mmol/L, measured by the force generated, showed a significant decrease with high extracellular glucose concentrations (11 mmol/L). Insulin caused a dose-dependent increase in arterial contraction induced by KCl. This increase was significant when arteries were stimulated with 80 mmol/L KCl in the presence of 5.5 mmol/L glucose, but when 40 mmol/L KCl was used, an increase was observed with both 5.5 and 11 mmol/L glucose. The insulin-induced contraction was significantly reduced in the presence of hyperimmune anti-endothelin serum and in the presence of endothelin receptor ET(A) and ET(B) antagonists PD 151,242 and BQ-788, respectively. These results suggest that hyperinsulinemia and hyperglycemia may contribute to hypertension in diabetes and that responses to insulin are mediated partially by endothelin, thus explaining why non-insulin-dependent diabetes mellitus patients show an increase in arterial pressure before the onset of nephropathy.

Purification and characterization of a variant of human prothrombin: prothrombin Segovia.

A dysprothrombin designated prothrombin Segovia was isolated from the plasma of an individual with normal prothrombin antigen and prothrombin activity lesser than 25% of the control prothrombin activity. Activation by prothrombinase complex showed a lower amidolytic than clotting activity, which suggests a lesser generation of active intermediates than normal prothrombin. When prothrombin Segovia was activated by prothrombinase complex in the absence of factor Va, no thrombin formation was found by functional activities. SDS-PAGE analysis of the molecules derived by activation with prothrombinase complex, Taipan snake venom and Echis carinatus venom showed an accumulation of molecules not cleaved at bond Arg320-Ile321. This was more evident with Echis carinatus venom, which only acts on this bond. Our data suggest that the alteration of prothrombin Segovia impairs the scission of bond Arg320-Ile321.

Error propagation in polarimetric demodulation.

The polarization analysis of light is typically carried out using modulation schemes. The light of an unknown polarization state is passed through a set of known modulation optics, and a detector is used to measure the total intensity passing the system. The modulation optics is modified several times, and, with the aid of several such measurements, the unknown polarization state of the light can be inferred. How to find the optimal demodulation process has been investigated in the past. However, since the modulation matrix has to be measured for a given instrument and the optical elements can present problems of repeatability, some uncertainty is present in the elements of the modulation matrix or covariances between these elements. We analyze in detail this issue, presenting analytical formulas for calculating the covariance matrix produced by the propagation of such uncertainties on the demodulation matrix, on the inferred Stokes parameters, and on the efficiency of the modulation process. We demonstrate that even if the covariance matrix of the modulation matrix is diagonal, the covariance matrix of the demodulation matrix is in general nondiagonal because matrix inversion is a nonlinear operation. This propagates through the demodulation process and induces correlations on the inferred Stokes parameters.

The altered expression of inflammation-related molecules and secretion of IL-6 and IL-8 by HUVEC from newborns with maternal inactive systemic lupus erythematosus is modified by estrogens.

Systemic lupus erythematosus (SLE) predominantly affects women, especially those in reproductive age. Genetic contributions to disease susceptibility as well as immune dysregulation, particularly persistent inflammatory responses, are considered essential features. Our aim was to determine whether human umbilical vein endothelial cells (HUVEC) isolated from healthy newborns to women with inactive SLE show inflammation-related abnormalities that might lead to an early development of SLE in the offsprings. HUVEC isolated from six women with inactive SLE were stimulated with 2.5 ng/mL of TNF-alpha and/or physiological and pharmacological doses of 17-I(2) estradiol (E2). Then the expression of VCAM-1, ICAM-1, E-selectin, toll-like receptor-9 (TLR-9), heat shock protein 70 (HSP70) and HSP90 were measured. The concentrations of IL-6, IL-8, and IL-10 were also determined in maternal serum and in TNF-alpha stimulated and non-stimulated HUVEC culture supernatant. HUVEC from children with no family history of autoimmune disease served as controls. Our results showed that in HUVEC from SLE+ mothers, a constitutively low expression of adhesion molecules was enhanced by TNF-alpha treatment. The E2 (1 ng/mL) increased the expression of adhesion molecules but had no effect upon TNF-alpha-treated cells. IL-6 was constitutively higher in SLE+ HUVEC, whereas IL-8 was lower; E2 treatment diminished the latter. The E2 had no effect upon IL-6 and IL-8 secretions in TNF-alpha-treated cells. SLE+ HUVEC showed a disordered cytoskeleton and overexpressed HSP70, HSP90, and TLR-9. Our results indicate that endothelial cells of newborns to SLE+ mothers are in a proinflammatory condition which can be upregulated by estrogens.

Anamorphic white light Fourier processor with holographic lenses.

Two anamorphic and achromatic Fourier processors were designed and constructed using diffractive and refractive cylindrical lenses. The diffractive lenses are holographic lenses recorded on silver halide material. In both processors the achromatic one-dimensional Fourier transform plane was obtained with two holographic lenses and one refractive cylindrical lens. The image with the same magnification in both directions at the output plane was formed with two different combinations of lenses. The differences between the two processors are analyzed, and in both cases the chromatic aberration in the Fourier plane and in the output plane is evaluated. Even though single cylindrical refractive lenses were used to image in one direction, good results were obtained.

Optimum modulation and demodulation matrices for solar polarimetry.

Both temporal and/or spatial modulation are mandatory in current solar polarimetry [Appl. Opt. 24, 3893 (1985); 26, 3838 (1987)]. The modulating and demodulating processes are mathematically described by matrices O and D, respectively, on whose structure the accuracy of Stokes parameter measurements depend. We demonstrate, based on the definition of polarimetric efficiency [Instituto de Astrofísica de Canarias Internal Report (1994); ASP Conf. Ser. 184, 3 (1999)], that the maximum efficiencies of an ideal polarimeter are unity for Stokes I and for (Q(2) + U(2) + V(2))(1/2) and that this occurs if and only if O(T)O is diagonal; given a general (possibly nonideal) modulation matrix O, the optimum demodulation matrix turns out to be D = (O(T)O)(-1)O(T); and the maximum efficiencies in the nonideal case are given by the rms value of the column elements of matrix O and are reached by modulation matrices such that O(T)O is diagonal. From these analytical results we distill two recipes useful in the practical design of polarimeters. Their usefulness is illustrated by discussing cases of currently available solar polarimeters. Although specifically devoted to solar polarimetry, the results here may be applied in practically all other branches of science for which polarimetric measurements are needed.

Thrombin-antithrombin complexes and prothrombin fragment 1+2 in aorto-coronary bypass surgery: relation to graft occlusion.

Graft thrombotic occlusion is a common complication in patients undergoing aorto-coronary bypass surgery. Clotting activation seems to contribute to the thrombotic event. We have determined the plasma concentrations of two hemostatic markers, thrombin-antithrombin (TAT) complexes and prothrombin fragment 1+2 (F 1+2) in 100 patients undergoing revascularization procedures of whom 81 underwent shunt angiography. Angiographically proven graft occlusion was present in 19 patients (23.5%). A significant increase of both parameters was observed immediately after surgery and on postoperative days 1 and 5 (p < 0.001), although a relationship to graft occlusion could not be demonstrated. However, the preoperative TAT concentration was higher in patients developing graft occlusion (p < 0.01). We conclude that there is a marked clotting activation in patients undergoing aorto-coronary bypass surgery, as demonstrated by elevated TAT and F 1+2 concentrations. Preoperative TAT values can be good markers of early graft occlusion.