Detalhe da pesquisa
1.
Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery.
Biochemistry
; 60(29): 2275-2284, 2021 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34259514
2.
Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Lancet Oncol
; 19(5): 649-659, 2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650362
3.
Corrigendum to "Impact of enzyme concentration and residence time on apparent activity recovery in jump dilution analysis" [Anal. Biochem. 416 (2011) 206-210].
Anal Biochem
; 645: 114637, 2022 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35249722
4.
A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Nat Chem Biol
; 11(6): 432-7, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25915199
5.
PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease.
Biochemistry
; 55(11): 1600-14, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26836503
6.
CARM1 Preferentially Methylates H3R17 over H3R26 through a Random Kinetic Mechanism.
Biochemistry
; 55(11): 1635-44, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26848779
7.
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
Biochemistry
; 55(11): 1645-51, 2016 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-26813693
8.
Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor.
Xenobiotica
; 46(3): 268-77, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26294260
9.
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Proc Natl Acad Sci U S A
; 110(19): 7922-7, 2013 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23620515
10.
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.
Blood
; 122(6): 1017-25, 2013 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23801631
11.
Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Drug Metab Dispos
; 43(7): 936-43, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25887455
12.
DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
J Pharmacol Exp Ther
; 350(3): 646-56, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24993360
13.
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Nat Chem Biol
; 8(11): 890-6, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23023262
14.
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²7 methylation by human polycomb repressive complex 2 and vSET.
Biochem J
; 453(2): 241-7, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23679895
15.
Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor.
Biopharm Drug Dispos
; 35(4): 237-52, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24415392
16.
Socioeconomic disparities in cataract surgery.
Curr Opin Ophthalmol
; 24(1): 74-8, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23108314
17.
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Proc Natl Acad Sci U S A
; 107(49): 20980-5, 2010 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078963
18.
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Proc Natl Acad Sci U S A
; 107(13): 5839-44, 2010 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20167803
19.
The importance of binding kinetics and drug-target residence time in pharmacology.
Br J Pharmacol
; 2023 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37160660
20.
Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9.
SLAS Discov
; 28(8): 376-384, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37625785