Detalhe da pesquisa
1.
Tau and Amyloid ß Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.
J Neurosci
; 43(32): 5870-5879, 2023 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37491315
2.
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.
Acta Neuropathol
; 139(3): 503-526, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31853635
3.
Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.
J Neurosci
; 38(50): 10595-10606, 2018 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355631
4.
Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo.
Neurobiol Dis
; 127: 582-590, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30910746
5.
Human Brain-Derived Aß Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.
J Neurosci
; 37(49): 11947-11966, 2017 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29101243
6.
Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.
Neurobiol Learn Mem
; 154: 141-157, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29906573
7.
Activation of peroxisome proliferator-activated receptor α stimulates ADAM10-mediated proteolysis of APP.
Proc Natl Acad Sci U S A
; 112(27): 8445-50, 2015 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26080426
8.
Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.
Int J Mol Sci
; 19(3)2018 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-29495441
9.
Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy.
J Biol Chem
; 288(12): 8299-8312, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23404502
10.
Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense.
J Immunol
; 189(2): 1002-13, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22706077
11.
Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.
J Biol Chem
; 287(46): 38922-35, 2012 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989886
12.
Non-neuronal cells exacerbate ß-amyloid aggregation in the aged brain.
J Neurosci
; 34(30): 9825-7, 2014 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25057186
13.
The native form of α-Synuclein: Monomer, tetramer, or a combination in equilibrium.
Mov Disord
; 30(14): 1870, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26230906
14.
PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity.
Brain Res
; 1710: 125-135, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593771
15.
Extracellular Forms of Aß and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.
Cell Rep
; 23(7): 1932-1938, 2018 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29768194
16.
Selective disruption of TLR2-MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.
J Clin Invest
; 128(10): 4297-4312, 2018 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990310
17.
Cryopreservation Maintains Functionality of Human iPSC Dopamine Neurons and Rescues Parkinsonian Phenotypes In Vivo.
Stem Cell Reports
; 9(1): 149-161, 2017 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28579395
18.
Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease.
J Alzheimers Dis
; 47(2): 385-402, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26401561
19.
HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice.
Cell Metab
; 22(2): 253-65, 2015 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26118928
20.
Regulation of cyclic AMP response element binding and hippocampal plasticity-related genes by peroxisome proliferator-activated receptor α.
Cell Rep
; 4(4): 724-37, 2013 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972989