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In recent years, non-small cell lung cancer treatment has been revolutionized. EGFR tyrosine kinase inhibitors and our improved understanding of its alterations have driven new diagnostic strategies. Liquid biopsies have emerged as a useful tool in these contexts, showing potential utility in early diagnosis combined with low-dose CT scans, as well as potential in monitoring treatment response and predicting the development of patients. We studied the circulating tumor DNA (ctDNA) of 38 EGFR-mutated non-small cell lung cancer patients at diagnosis in different moments of their disease by liquid biopsy techniques. Our results show that mean overall survival was significantly lower when a liquid biopsy was positive for the detection of EGFR mutations compared with wild-type patients in their liquid biopsy in both univariate (29 ± 4 vs. 104 ± 19 months; p = 0.004) and multivariate analysis (p = 0.008). Taking this into consideration, liquid biopsies could be key to improving the control of this disease.
RESUMO
INTRODUCTION: This study sets out to find out the incidence and other epidemiological characteristics of bronchopulmonary cancer in patients living in Cantabria and Castilla y Leon (Spain) and comparing the current data obtained in the last communities with that obtained 10 years ago in a similar study. PATIENTS AND METHODS: Prospective, multicentre study using information (age, sex, residence, smoking habits and histology) obtained from all patients diagnosed during the year 2007. RESULTS: A total of 1486 patients were included--1295 males (87.1%) and 191 females (12.9%)--, of whom 1145 lived in Castilla y Leon--1010 males (88.2%) and 135 females (11.8%)--, and 341 in Cantabria--285 males (83.6%) and 56 females (16.4%)--. The incidence rates per 100,000 inhabitants adjusted to the world standard population were significantly higher in Cantabria [29.53; (males: 52.9; females: 9.76)] than in Castilla y Leon [21.35; (males: 38.31; females: 5.58)]. A total of 90.24% were smokers (males: 96.12% and women: 49.17%). The main histology types were: squamous, 32, 82%; adenocarcinoma, 28.74%, and small cell carcinomas, 18.33%. In Castilla y Leon, from 1997 to 2007, the numbers went from 920 to 1010 in males and from 95 to 135 in females (a crude rate increase of 10.5% in males and 43% in females), and showed a decrease in squamous tumours and an increase in adenocarcinomas. CONCLUSIONS: The incidence rates of bronchopulmonary cancer in 2007 were significantly higher in Cantabria than those of Castilla y Leon. The 2007 rates in this community were higher than in 1997 in both males and females.
Assuntos
Neoplasias Pulmonares/epidemiologia , Idoso , Neoplasias Brônquicas/epidemiologia , Feminino , Humanos , Incidência , Masculino , Estudos Prospectivos , Espanha/epidemiologiaRESUMO
Introducción Dada la importancia sanitaria del carcinoma broncopulmonar, hemos planteado un estudio para conocer su incidencia y otros aspectos epidemiológicos en los pacientes residentes en Cantabria y en Castilla y León, comparando en esta comunidad los datos actuales con los obtenidos 10 años antes en un estudio similar. Pacientes y métodos Obtención prospectiva y multicéntrica de información (edad, sexo, residencia, tabaquismo e histología) en todos los pacientes diagnosticados a lo largo del año 2007. Resultados Se incluyó a 1.486 pacientes 1.295 varones (87,1%) y 191 mujeres (12,9%), de los que 1.145 residían en Castilla y León 1.010 varones (88,2%) y 135 mujeres (11,8%), y 341 en Cantabria 285 varones (83,6%) y 56 mujeres (16,4%). Las tasas de incidencia por 100.000 habitantes ajustadas a la población mundial estándar han sido significativamente superiores en Cantabria (29,53; varones: 52,9; mujeres: 9,76) que en Castilla y León (21,35; varones: 38,31; mujeres: 5,58). Habían sido fumadores un 90,24% (varones: 96,12%; mujeres: 49,17%). Los principales tipos histológicos fueron los tumores escamosos, un 32,82%, adenocarcinomas un 28,74% y carcinomas de células pequeñas un 18,33%. En Castilla y León, desde 1997 a 2007, el número de varones ha pasado de 920 a 1.010 y el de mujeres de 95 a 135 (incremento de tasas brutas: un 10,5% en varones y un 43% en mujeres), objetivándose un descenso de los tumores escamosos y un aumento de los adenocarcinomas. Conclusiones En 2007 las tasas de incidencia del cáncer broncopulmonar eran en Cantabria significativamente superiores a las de Castilla y León. En esta comunidad las tasas de 2007 han sido superiores a las de 1997, tanto en varones como en mujeres(AU)
Introduction This study sets out to find out the incidence and other epidemiological characteristics of bronchopulmonary cancer in patients living in Cantabria and Castilla y Leon (Spain) and comparing the current data obtained in the last communities with that obtained 10 years ago in a similar study. Patients and methods Prospective, multicentre study using information (age, sex, residence, smoking habits and histology) obtained from all patients diagnosed during the year 2007. Results A total of 1486 patients were included 1295 males (87.1%) and 191 females (12.9%), of whom 1145 lived in Castilla y Leon 1010 males (88.2%) and 135 females (11.8%), and 341 in Cantabria 285 males (83.6%) y 56 females (16.4%). The incidence rates per 100,000 inhabitants adjusted to the world standard population were significantly higher in Cantabria [29.53; (males: 52.9; females: 9.76)] than in Castilla y Leon [21.35; (males: 38.31; females: 5.58)]. A total of 90.24% were smokers (males: 96.12% and women: 49.17%). The main histology types were: squamous, 32, 82%; adenocarcinoma, 28.74%, and small cell carcinomas, 18.33%. In Castilla y Leon, from 1997 to 2007, the numbers went from 920 to 1010 in males and from 95 to 135 in females (a crude rate increase of 10.5% in males and 43% in females), and showed a decrease in squamous tumours and an increase in adenocarcinomas. Conclusions The incidence rates of bronchopulmonary cancer in 2007 were significantly higher in Cantabria than those of Castilla y Leon. The 2007 rates in this community were higher than in 1997 in both males and females(AU)