Detalhe da pesquisa
1.
Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Bioorg Med Chem Lett
; 30(23): 127521, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32882417
2.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055941
3.
Estimation of the extent of in vivo formation of a mutagenic aromatic amine from a potent thyromimetic compound: correlation of in vitro and in vivo findings.
Chem Res Toxicol
; 24(6): 905-12, 2011 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21574629
4.
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
ACS Med Chem Lett
; 12(5): 827-835, 2021 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34055233
5.
Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
J Med Chem
; 64(5): 2714-2724, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33591748
6.
Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
J Med Chem
; 64(3): 1454-1480, 2021 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33492963
7.
Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.
ACS Med Chem Lett
; 11(9): 1766-1772, 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32944145
8.
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.
ACS Med Chem Lett
; 11(12): 2510-2518, 2020 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33335675
9.
Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist.
ACS Med Chem Lett
; 11(6): 1221-1227, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551004
10.
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
J Med Chem
; 62(21): 9931-9946, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31638797
11.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem
; 62(5): 2265-2285, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30785748
12.
Identification of potent tricyclic prodrug S1P1 receptor modulators.
Medchemcomm
; 8(4): 725-729, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108791
13.
Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.
Bioanalysis
; 8(4): 265-74, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26807991
14.
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1).
J Med Chem
; 59(13): 6248-64, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27309907
15.
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
J Med Chem
; 59(6): 2820-40, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26924461
16.
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.
ACS Med Chem Lett
; 7(3): 283-8, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26985316
17.
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
J Med Chem
; 59(24): 11138-11147, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002964
18.
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.
J Med Chem
; 59(21): 9837-9854, 2016 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27726358
19.
Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.
ACS Med Chem Lett
; 6(7): 770-5, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191364
20.
Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
ACS Med Chem Lett
; 6(8): 908-12, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288692