Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of Thiazolo[3, 2-a]Pyrimidine derivatives as novel RNase H inhibitors.
Bioorg Chem
; 148: 107495, 2024 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38805850
2.
Structure-Based Design of Novel Thiazolone[3,2-a]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy.
Molecules
; 29(9)2024 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38731613
3.
Mutations in the 3'-PPT Lead to HIV-1 Replication without Integration.
J Virol
; 96(14): e0067622, 2022 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-35758669
4.
Targeting SARS-CoV-2 Main Protease: A Successful Story Guided by an In Silico Drug Repurposing Approach.
J Chem Inf Model
; 63(11): 3601-3613, 2023 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37227780
5.
Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds.
Bioorg Med Chem
; 90: 117376, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37336083
6.
Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach.
Molecules
; 27(21)2022 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36364347
7.
Flavonoids and Acid-Hydrolysis derivatives of Neo-Clerodane diterpenes from Teucrium flavum subsp. glaucum as inhibitors of the HIV-1 reverse transcriptase-associated RNase H function.
J Enzyme Inhib Med Chem
; 36(1): 749-757, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715562
8.
Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H.
Arch Pharm (Weinheim)
; 354(9): e2100123, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34008218
9.
Natural and Nature-Derived Products Targeting Human Coronaviruses.
Molecules
; 26(2)2021 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33467029
10.
Chemical Characterization and Anti-HIV-1 Activity Assessment of Iridoids and Flavonols from Scrophularia trifoliata.
Molecules
; 26(16)2021 Aug 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34443358
11.
Exploring New Scaffolds for the Dual Inhibition of HIV-1 RT Polymerase and Ribonuclease Associated Functions.
Molecules
; 26(13)2021 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34201561
12.
Quercetin Blocks Ebola Virus Infection by Counteracting the VP24 Interferon-Inhibitory Function.
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32366711
13.
Scaffold hopping and optimisation of 3',4'-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H.
J Enzyme Inhib Med Chem
; 35(1): 1953-1963, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33143469
14.
2-(Arylamino)-6-(trifluoromethyl)nicotinic Acid Derivatives: New HIV-1 RT Dual Inhibitors Active on Viral Replication.
Molecules
; 25(6)2020 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32183488
15.
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.
Molecules
; 25(5)2020 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151066
16.
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
J Enzyme Inhib Med Chem
; 34(1): 55-74, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362381
17.
Identification of Myricetin as an Ebola Virus VP35-Double-Stranded RNA Interaction Inhibitor through a Novel Fluorescence-Based Assay.
Biochemistry
; 57(44): 6367-6378, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30298725
18.
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
Nucleic Acids Res
; 44(5): 2310-22, 2016 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26850643
19.
Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding.
Chembiochem
; 18(4): 374-377, 2017 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992102
20.
Isatin thiazoline hybrids as dual inhibitors of HIV-1 reverse transcriptase.
J Enzyme Inhib Med Chem
; 32(1): 130-136, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27766892