Detalhe da pesquisa
1.
Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine.
Blood
; 119(5): 1240-7, 2012 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22160381
2.
Characterization of acute biliary hyperplasia in Fisher 344 rats administered the indole-3-carbinol analog, NSC-743380.
Toxicol Appl Pharmacol
; 281(3): 303-9, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25448049
3.
Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice.
Int J Toxicol
; 33(2): 75-85, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24639139
4.
Mouse pharmacokinetics and metabolism of the phenylurea thiocarbamate NSC 161128.
Cancer Chemother Pharmacol
; 90(2): 161-174, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35896839
5.
Population Pharmacokinetics of Z-Endoxifen in Patients With Advanced Solid Tumors.
J Clin Pharmacol
; 62(9): 1121-1131, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35358345
6.
Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs.
Mol Cancer Ther
; 21(10): 1510-1523, 2022 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35876604
7.
Development and validation of an LC-MS/MS generic assay platform for small molecule drug bioanalysis.
J Pharm Biomed Anal
; 203: 114185, 2021 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34111734
8.
Phase 1 study of Z-endoxifen in patients with advanced gynecologic, desmoid, and hormone receptor-positive solid tumors.
Oncotarget
; 12(4): 268-277, 2021 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33659039
9.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem
; 64(8): 4913-4946, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822623
10.
Intravenous 5-fluoro-2'-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 85(5): 979-993, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32314030
11.
Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.
Clin Cancer Res
; 14(11): 3529-35, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18519786
12.
Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.
Cancer Chemother Pharmacol
; 62(3): 457-64, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18008070
13.
Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 862(1-2): 168-74, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18155649
14.
Molecular Pharmacodynamics-Guided Scheduling of Biologically Effective Doses: A Drug Development Paradigm Applied to MET Tyrosine Kinase Inhibitors.
Mol Cancer Ther
; 17(3): 698-709, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29444985
15.
NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma.
Clin Cancer Res
; 24(23): 5830-5840, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30061364
16.
A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.
Clin Cancer Res
; 12(19): 5826-33, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17020990
17.
Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice.
Clin Cancer Res
; 12(24): 7483-91, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17138702
18.
High performance liquid chromatographic analysis and preclinical pharmacokinetics of the heteroarotinoid antitumor agent, SHetA2.
Cancer Chemother Pharmacol
; 58(5): 561-9, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16534614
19.
Preclinical pharmacology of the novel antitumor agent adaphostin, a tyrphostin analog that inhibits bcr/abl.
Cancer Chemother Pharmacol
; 57(5): 607-14, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16331493
20.
Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection.
J Chromatogr B Analyt Technol Biomed Life Sci
; 831(1-2): 147-55, 2006 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-16364698