Detalhe da pesquisa
1.
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.
Cell
; 150(5): 895-908, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22939619
2.
Single-stranded siRNAs activate RNAi in animals.
Cell
; 150(5): 883-94, 2012 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-22939618
3.
Establishing an environment in which rigorous scientific inquiry is practiced: a personal journey.
Nucleic Acids Res
; 50(13): 7216-7223, 2022 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35801855
4.
Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.
Nucleic Acids Res
; 50(14): 8107-8126, 2022 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35848907
5.
Perinuclear positioning of endosomes can affect PS-ASO activities.
Nucleic Acids Res
; 49(22): 12970-12985, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34878127
6.
Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.
Nucleic Acids Res
; 49(5): 2721-2739, 2021 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33577678
7.
Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
Nucleic Acids Res
; 49(14): 8277-8293, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244781
8.
Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 49(16): 9026-9041, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417625
9.
Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs.
Nucleic Acids Res
; 49(4): 1828-1839, 2021 02 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33544849
10.
Antisense technology: A review.
J Biol Chem
; 296: 100416, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33600796
11.
Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.
Nucleic Acids Res
; 48(17): 9840-9858, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32870273
12.
Phosphorothioate modified oligonucleotide-protein interactions.
Nucleic Acids Res
; 48(10): 5235-5253, 2020 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32356888
13.
Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Nucleic Acids Res
; 48(3): 1372-1391, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31840180
14.
Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.
Nucleic Acids Res
; 48(4): 1691-1700, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980820
15.
Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.
Nucleic Acids Res
; 47(20): 10865-10880, 2019 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31495875
16.
mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.
Nucleic Acids Res
; 47(13): 6900-6916, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31165876
17.
Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Nucleic Acids Res
; 47(11): 5465-5479, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31034558
18.
Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry.
J Am Chem Soc
; 142(21): 9661-9674, 2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32374993
19.
The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.
J Am Chem Soc
; 142(35): 14754-14771, 2020 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786803
20.
Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
J Am Chem Soc
; 142(16): 7456-7468, 2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32202774