Detalhe da pesquisa
1.
Transcriptional silencing of fetal hemoglobin expression by NonO.
Nucleic Acids Res
; 49(17): 9711-9723, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34379783
2.
Pharmacologic induction of PGC-1α stimulates fetal haemoglobin gene expression.
Br J Haematol
; 197(1): 97-109, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35118652
3.
A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.
Blood Cells Mol Dis
; 69: 1-9, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227829
4.
Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic ß-type globin genes.
Blood
; 125(9): 1477-87, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25561507
5.
The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.
Blood
; 126(3): 386-96, 2015 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-26031919
6.
Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (뫧)0 -thalassemia deletion.
Am J Hematol
; 97(4): E156-E158, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35045200
7.
Reactivation of Fetal Hemoglobin for Treating ß-Thalassemia and Sickle Cell Disease.
Adv Exp Med Biol
; 1013: 177-202, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29127681
8.
Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells.
PLoS Genet
; 10(5): e1004339, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24811540
9.
Developmental transcriptome analysis of human erythropoiesis.
Hum Mol Genet
; 23(17): 4528-42, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24781209
10.
Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis.
Blood
; 133(22): 2455-2459, 2019 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-30992270
11.
The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).
Haematologica
; 101(6): 688-97, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858356
12.
Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons.
Blood
; 129(2): 260-263, 2017 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908882
13.
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes.
Proc Natl Acad Sci U S A
; 108(46): 18808-13, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22042865
14.
Roles of Nuclear Orphan Receptors TR2 and TR4 during Hematopoiesis.
Genes (Basel)
; 15(5)2024 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38790192
15.
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
Blood
; 117(1): 299-308, 2011 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-20870902
16.
Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease.
Biol Blood Marrow Transplant
; 16(6): 751-71, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20116439
17.
TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1.
Blood Cells Mol Dis
; 55(4): 316-7, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26460253
18.
Invertebrate Trehalose-6-Phosphate Synthase Gene: Genetic Architecture, Biochemistry, Physiological Function, and Potential Applications.
Front Physiol
; 9: 30, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29445344
19.
Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease.
Exp Hematol
; 50: 46-52, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28238805
20.
Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays.
Cell Signal
; 40: 73-80, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28867658