Detalhe da pesquisa
1.
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett
; 25(5): 1104-9, 2015 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666823
2.
Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett
; 23(5): 1238-44, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23374866
3.
Discovery of INT131: a selective PPARγ modulator that enhances insulin sensitivity.
Bioorg Med Chem
; 21(4): 979-92, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23294830
4.
A novel series of IKKß inhibitors part II: description of a potent and pharmacologically active series of analogs.
Bioorg Med Chem Lett
; 21(1): 423-6, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074992
5.
A novel series of IKKß inhibitors part I: Initial SAR studies of a HTS hit.
Bioorg Med Chem Lett
; 21(1): 417-22, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21074993
6.
Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3Kδ Inhibitors.
J Med Chem
; 59(1): 431-47, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26652588
7.
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430).
J Med Chem
; 59(15): 7252-67, 2016 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411843
8.
Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease.
J Med Chem
; 58(1): 480-511, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25469863
9.
Discovery and in vivo evaluation of dual PI3Kß/δ inhibitors.
J Med Chem
; 55(17): 7667-85, 2012 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-22876881
10.
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
J Med Chem
; 55(20): 8559-81, 2012 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22924688