Detalhe da pesquisa
1.
The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose.
Biomolecules
; 13(9)2023 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37759755
2.
Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans.
Int J Clin Pharmacol Ther
; 50(8): 584-94, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22578199
3.
A novel fluorogenic substrate for the measurement of endothelial lipase activity.
J Lipid Res
; 52(2): 374-82, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21062953
4.
Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition.
J Cardiovasc Pharmacol
; 55(5): 459-68, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20051879
5.
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.
Clin Pharmacol Ther
; 107(1): 102-111, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31709525
6.
Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats.
J Pharmacol Exp Ther
; 324(3): 894-901, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083913
7.
7-fluoroindazoles as potent and selective inhibitors of factor Xa.
J Med Chem
; 51(2): 282-97, 2008 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18159923
8.
Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist.
Eur J Pharmacol
; 590(1-3): 333-42, 2008 Aug 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599033
9.
Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif.
Bioorg Med Chem Lett
; 18(9): 2865-70, 2008 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18420408
10.
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
J Med Chem
; 50(8): 1727-30, 2007 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17361995
11.
Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment.
Bioorg Med Chem Lett
; 17(23): 6489-92, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17933531
12.
Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies.
Bioorg Med Chem Lett
; 17(23): 6623-8, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17942308
13.
Chronic drug-induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell-derived cardiomyocytes.
Br J Pharmacol
; 174(21): 3766-3779, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28094846
14.
Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists.
J Med Chem
; 49(11): 3402-11, 2006 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16722660
15.
A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.
J Biomol Screen
; 21(1): 1-11, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26170255
16.
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
J Med Chem
; 48(6): 1725-8, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771419
17.
Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors.
Peptides
; 26(4): 683-90, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15752584
18.
Mer receptor tyrosine kinase signaling participates in platelet function.
Arterioscler Thromb Vasc Biol
; 24(6): 1118-23, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15130911
19.
Characterization of an anesthetized dog model of transient cardiac ischemia and rapid pacing: a pilot study for preclinical assessment of the potential for proarrhythmic risk of novel drug candidates.
J Pharmacol Toxicol Methods
; 72: 72-84, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25450838
20.
Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes.
J Histochem Cytochem
; 60(9): 694-705, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22740344