Detalhe da pesquisa
1.
Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction.
Bioorg Med Chem
; 106: 117755, 2024 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38749343
2.
DNA Sequence Specificity Reveals a Role of the HLTF HIRAN Domain in the Recognition of Trinucleotide Repeats.
Biochemistry
; 2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35608245
3.
Protein-Protein Interactions in Translesion Synthesis.
Molecules
; 26(18)2021 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34577015
4.
Small molecules block the interaction between porcine reproductive and respiratory syndrome virus and CD163 receptor and the infection of pig cells.
Virol J
; 17(1): 116, 2020 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32727587
5.
Probing the Protein-Protein Interaction Between the ATRXADD Domain and the Histone H3 Tail.
Molecules
; 25(7)2020 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32218364
6.
Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1.
J Chem Inf Model
; 58(11): 2266-2277, 2018 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30289707
7.
A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor.
Biochim Biophys Acta Gen Subj
; 1861(2): 168-177, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-27825830
8.
Benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one derivatives as Aurora A kinase inhibitors: LQTA-QSAR analysis and detailed systematic validation of the developed model.
Mol Divers
; 19(4): 965-74, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26183841
9.
Identification of new novel scaffold for Aurora A inhibition by pharmacophore modeling and virtual screening.
Mol Divers
; 18(4): 853-63, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25112687
10.
Integrated computational tools for identification of CCR5 antagonists as potential HIV-1 entry inhibitors: homology modeling, virtual screening, molecular dynamics simulations and 3D QSAR analysis.
Molecules
; 19(4): 5243-65, 2014 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24762964
11.
Scaffold hopping for identification of novel D(2) antagonist based on 3D pharmacophore modelling of illoperidone analogs.
Mol Divers
; 16(2): 367-75, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22161148
12.
Exploration of new scaffolds as potential MAO-A inhibitors using pharmacophore and 3D-QSAR based in silico screening.
Bioorg Med Chem Lett
; 21(8): 2419-24, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21397504
13.
Translesion synthesis inhibitors as a new class of cancer chemotherapeutics.
Expert Opin Investig Drugs
; 30(1): 13-24, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33179552
14.
Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor.
Mol Ther Oncolytics
; 20: 265-276, 2021 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33614910
15.
Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.
Eur J Med Chem
; 163: 320-332, 2019 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30529635
16.
Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors.
J Med Chem
; 62(8): 3873-3885, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30896941
17.
A metadynamic approach to understand the recognition mechanism of the histone H3 tail with the ATRXADD domain.
Biochim Biophys Acta Gene Regul Mech
; 1861(6): 594-602, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29730439
18.
Design, synthesis, pharmacological evaluation and computational studies of 1-(biphenyl-4-yl)-2-[4-(substituted phenyl)-piperazin-1-yl]ethanones as potential antipsychotics.
Eur J Med Chem
; 74: 358-65, 2014 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24486417
19.
Design, synthesis, pharmacological evaluation and descriptor based similarities study of N,N-diphenyl-2-[4-(substituted phenyl)piperazin-1-yl]acetamides as potential antipsychotics.
Med Chem
; 8(6): 1069-75, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22779792