Detalhe da pesquisa
1.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther
; 343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935731
2.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett
; 22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465635
3.
ABT-869, a multitargeted receptor tyrosine kinase inhibitor, reduces tumor microvascularity and improves vascular wall integrity in preclinical tumor models.
J Pharmacol Exp Ther
; 338(1): 134-42, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21505059
4.
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML.
Blood
; 113(17): 4052-62, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144991
5.
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
Bioorg Med Chem Lett
; 21(18): 5620-4, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778056
6.
Substituted 4-amino-1H-pyrazolo[3,4-d]pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases.
Bioorg Med Chem Lett
; 20(20): 6067-71, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20817523
7.
Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 20(8): 2452-5, 2010 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20346655
8.
Effect of the multitargeted receptor tyrosine kinase inhibitor, ABT-869 [N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea], on blood pressure in conscious rats and mice: reversal with antihypertensive agents and effect on tumor growth inhibition.
J Pharmacol Exp Ther
; 329(3): 928-37, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19255283
9.
Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605.
BMC Cancer
; 9: 314, 2009 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19732452
10.
ETA receptor blockade with atrasentan prevents hypertension with the multitargeted tyrosine kinase inhibitor ABT-869 in telemetry-instrumented rats.
J Cardiovasc Pharmacol
; 53(2): 173-8, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19188829
11.
Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 19(6): 1718-21, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19217287
12.
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
J Med Chem
; 51(5): 1231-41, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260617
13.
In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor.
Leuk Res
; 32(7): 1091-100, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18160102
14.
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2691-5, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362070
15.
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Bioorg Med Chem Lett
; 18(1): 386-90, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023347
16.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
17.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
18.
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.
Mol Cancer Ther
; 5(4): 1007-13, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648572
19.
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.
Mol Cancer Ther
; 5(4): 995-1006, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648571
20.
Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J Med Chem
; 49(13): 3832-49, 2006 Jun 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16789740