Detalhe da pesquisa
1.
The Genetic Drivers of Juvenile, Young, and Early-Onset Parkinson's Disease in India.
Mov Disord
; 39(2): 339-349, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38014556
2.
A Fixable Fluorescence-Quenched Substrate for Quantitation of Lysosomal Glucocerebrosidase Activity in Both Live and Fixed Cells.
Angew Chem Int Ed Engl
; 62(40): e202309306, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37582679
3.
HIV control is mediated in part by CD8+ T-cell targeting of specific epitopes.
J Virol
; 88(22): 12937-48, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25165115
4.
Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Elife
; 122023 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37874617
5.
Specific inhibition of sensitized protein tyrosine phosphatase 1B (PTP1B) with a biarsenical probe.
Bioconjug Chem
; 23(2): 272-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22263876
6.
Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Science
; 377(6612): 1290-1298, 2022 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36007018
7.
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Dev Cell
; 56(3): 260-276.e7, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33308480
8.
ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann-Pick type C.
Nat Cell Biol
; 21(10): 1206-1218, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31548609
9.
Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex.
Science
; 355(6331): 1306-1311, 2017 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336668