Detalhe da pesquisa
1.
Ugi 5-center-4-component reaction of α-amino aldehydes and its application in synthesis of 2-oxopiperazines.
Mol Divers
; 28(1): 229-248, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38104301
2.
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
EMBO J
; 38(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530478
3.
Synthesis and biological evaluation of novel 3-(5-substituted-1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with a dual affinity for serotonin 5-HT1A receptor and SERT.
Bioorg Chem
; 141: 106903, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37827015
4.
Computer-Aided Design and Synthesis of a New Class of PEX14 Inhibitors: Substituted 2,3,4,5-Tetrahydrobenzo[F][1,4]oxazepines as Potential New Trypanocidal Agents.
J Chem Inf Model
; 61(10): 5256-5268, 2021 10 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34597510
5.
Identification of the Primary Structure of Selenium-Containing Polysaccharides Selectively Inhibiting T-Cell Proliferation.
Molecules
; 26(17)2021 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500837
6.
Synthesis of new 4-butyl-arylpiperazine-3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives and evaluation for their 5-HT1A and D2 receptor affinity and serotonin transporter inhibition.
Bioorg Chem
; 97: 103662, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32086055
7.
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.
Bioorg Chem
; 98: 103717, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32171994
8.
Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide.
J Biol Chem
; 293(28): 11088-11099, 2018 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29784881
9.
Synthesis and biological investigations of 3ß-aminotropane arylamide derivatives with atypical antipsychotic profile.
Med Chem Res
; 27(8): 1906-1928, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30100693
10.
Comparison of enzymatic properties and small molecule inhibition of γ-glutamyltranspeptidases from pathogenic and commensal bacteria.
Biol Chem
; 398(3): 341-357, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27636829
11.
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Bioorg Med Chem
; 22(19): 5410-27, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25150088
12.
Expanding the substrate scope of Ugi five-center, four-component reaction U-5C-4CR): ketones as coupling partners for secondary amino acids.
Mol Divers
; 18(1): 61-77, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24154732
13.
Synthesis of new perhydropyrrolo[1,2-a]pyrazine derivatives and their evaluation in animal models of epilepsy.
Molecules
; 19(10): 15955-81, 2014 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25295751
14.
Multicomponent synthesis and anticonvulsant activity of monocyclic 2,6-diketopiperazine derivatives.
Med Chem Res
; 23: 2007-2018, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24587688
15.
Structure-activity relationships of the aromatic site in novel anticonvulsant pyrrolo[1,2-a]pyrazine derivatives.
Bioorg Med Chem Lett
; 23(22): 6106-10, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24095092
16.
Development of novel PEX5-PEX14 protein-protein interaction (PPI) inhibitors based on an oxopiperazine template.
Eur J Med Chem
; 258: 115587, 2023 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37406382
17.
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Eur J Med Chem
; 243: 114778, 2022 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36194937
18.
DYRK1A Kinase Inhibitors Promote ß-Cell Survival and Insulin Homeostasis.
Cells
; 10(9)2021 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34571911
19.
Relationship between selenium accumulation and mycelial cell composition in Lentinula edodes (Berk.) cultures.
J Toxicol Environ Health A
; 73(17-18): 1211-9, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20706946
20.
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
Chem Commun (Camb)
; 56(31): 4360-4363, 2020 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32195483