Detalhe da pesquisa
1.
Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease.
N Engl J Med
; 378(4): 321-330, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29365294
2.
Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients.
Alzheimers Dement
; 12(2): 110-120, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26238576
3.
Challenges, solutions, and recommendations for Alzheimer's disease combination therapy.
Alzheimers Dement
; 12(5): 623-30, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27017906
4.
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis.
Proc Natl Acad Sci U S A
; 109(38): 15502-7, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22927427
5.
Amyloid-ß (Aß) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice.
Mol Neurodegener
; 18(1): 59, 2023 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37649100
6.
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease.
Alzheimers Dement
; 8(4): 261-71, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22672770
7.
Melanoma-Secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.
Cancer Discov
; 12(5): 1314-1335, 2022 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35262173
8.
Animal models for neural diseases.
Toxicol Pathol
; 39(1): 167-9, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21119053
9.
A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system.
Ann Neurol
; 66(1): 48-54, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19360898
10.
Advancing combination therapy for Alzheimer's disease.
Alzheimers Dement (N Y)
; 6(1): e12073, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33043108
11.
Anti-Aß antibody target engagement: commentary regarding Watt et al. Acta Neuropathol 127:803-810 (2014).
Acta Neuropathol
; 128(4): 609-10, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25120192
12.
Pharmacokinetics and Pharmacodynamics of LY2599666, a PEG-Linked Antigen Binding Fragment that Targets Soluble Monomer Amyloid-ß.
J Alzheimers Dis
; 68(1): 137-144, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30741684
13.
ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
Neuron
; 41(2): 193-202, 2004 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741101
14.
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.
Nat Neurosci
; 5(5): 452-7, 2002 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-11941374
15.
Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia.
Alzheimers Dement (N Y)
; 4: 652-660, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30511011
16.
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.
Mol Neurodegener
; 13(1): 65, 2018 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-30558641
17.
Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics.
Curr Alzheimer Res
; 4(2): 179-84, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17430244
18.
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.
J Neurosci
; 25(3): 629-36, 2005 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-15659599
19.
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques.
J Exp Med
; 213(5): 667-75, 2016 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27091843
20.
Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice.
J Neurosci
; 23(21): 7889-96, 2003 Aug 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-12944519