Detalhe da pesquisa
1.
MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition.
J Pharmacol Exp Ther
; 355(3): 397-409, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26407721
2.
A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins.
Science
; 376(6599): 1321-1327, 2022 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709255
3.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475697
4.
Substituted dipiperidine alcohols as potent CCR2 antagonists.
Bioorg Med Chem Lett
; 18(12): 3562-4, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18487045
5.
Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.
Bioorg Med Chem Lett
; 18(24): 6468-70, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18990568
6.
Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
ACS Med Chem Lett
; 9(7): 685-690, 2018 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30034601
7.
Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists.
J Med Chem
; 50(23): 5561-3, 2007 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17929797
8.
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J Med Chem
; 60(7): 2983-2992, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28245354
9.
The discovery of N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): a potent and selective glucagon receptor antagonist.
J Med Chem
; 57(6): 2601-10, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24527772
10.
A novel method for the preparation of 4-arylimidazolones.
Org Lett
; 15(11): 2830-3, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23713942
11.
Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists.
Bioorg Med Chem Lett
; 17(21): 5964-8, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17869105
12.
Asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB.
J Am Chem Soc
; 125(28): 8561-5, 2003 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-12848564