Detalhe da pesquisa
1.
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and ß2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD).
Bioorg Med Chem Lett
; 41: 127975, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753262
2.
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
J Pharmacol Exp Ther
; 352(3): 559-67, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25576075
3.
Discovery of a Potent, Selective, and Orally Bioavailable Tool Compound for Probing the Role of Lysophosphatidic Acid Type 2 Receptor Antagonists in Fibrotic Disorders.
J Med Chem
; 66(8): 5622-5656, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017110
4.
Optimization of M3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD.
J Med Chem
; 66(16): 11476-11497, 2023 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-37561958
5.
Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and ß2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases.
J Med Chem
; 65(15): 10233-10250, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35901125
6.
Design, Synthesis, and Biological Characterization of Inhaled p38α/ß MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases.
J Med Chem
; 65(10): 7170-7192, 2022 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35546685
7.
Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease.
J Med Chem
; 64(13): 9100-9119, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34142835
8.
Functionalized pyrazoles and pyrazolo[3,4-d]pyridazinones: Synthesis and evaluation of their phosphodiesterase 4 inhibitory activity.
Bioorg Med Chem
; 18(10): 3506-17, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413313
9.
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1).
J Med Chem
; 50(7): 1571-83, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17352462
10.
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2).
J Med Chem
; 50(7): 1693-7, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17352463
11.
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
J Med Chem
; 60(24): 10026-10046, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29200281
12.
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).
J Med Chem
; 49(17): 5051-8, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913695
13.
Erythroid differentiation ability of butyric acid analogues: identification of basal chemical structures of new inducers of foetal haemoglobin.
Eur J Pharmacol
; 752: 84-91, 2015 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25701725
14.
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.
J Med Chem
; 57(3): 793-816, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400806
15.
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives.
Bioorg Med Chem
; 14(10): 3263-74, 2006 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16460950
16.
Effects of 3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a novel nonsteroidal estrogen agonist/antagonist, on reproductive and nonreproductive tissue.
J Pharmacol Exp Ther
; 300(3): 802-9, 2002 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-11861784
17.
Pharmacological actions of a novel, potent, tissue-selective benzopyran estrogen.
J Pharmacol Exp Ther
; 303(1): 196-203, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12235251
18.
Synthesis, pharmacological evaluation, and structure-activity relationships of benzopyran derivatives with potent SERM activity.
Bioorg Med Chem
; 12(14): 3763-82, 2004 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15210143