Detalhe da pesquisa
1.
Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose-modified nucleic acids.
J Org Chem
; 80(6): 3083-91, 2015 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25723361
2.
Rigid 2',4'-difluororibonucleosides: synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase.
J Org Chem
; 79(12): 5627-35, 2014 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-24873952
3.
Dramatic effect of furanose C2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom.
J Am Chem Soc
; 135(14): 5344-7, 2013 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-23521511
4.
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing.
Nucleic Acids Res
; 38(13): 4547-57, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20413581
5.
Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.
Biochemistry
; 49(47): 10166-78, 2010 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21028906
6.
Chemically modified siRNA: tools and applications.
Drug Discov Today
; 13(19-20): 842-55, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614389
7.
Backbone FC-H···O hydrogen bonds in 2'F-substituted nucleic acids.
Angew Chem Int Ed Engl
; 52(46): 12065-8, 2013 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24115468
8.
Locked 2'-Deoxy-2',4'-Difluororibo Modified Nucleic Acids: Thermal Stability, Structural Studies, and siRNA Activity.
ACS Chem Biol
; 10(9): 2016-23, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26053215
9.
Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT.
ACS Chem Biol
; 10(9): 2024-33, 2015 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26131619
10.
Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity.
Nucleic Acid Ther
; 24(5): 336-43, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25162466
11.
The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues.
Nucleic Acid Ther
; 23(1): 81-7, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23289589
12.
Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery.
Biomaterials
; 34(33): 8408-15, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23932248
13.
Designing chemically modified oligonucleotides for targeted gene silencing.
Chem Biol
; 19(8): 937-54, 2012 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22921062
14.
The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity.
Biomaterials
; 33(25): 5955-65, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22656448
15.
Antisense 2'-Deoxy, 2'-Fluroarabino Nucleic Acids (2'F-ANAs) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids.
Mol Ther Nucleic Acids
; 1: e43, 2012 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23344235
16.
siRNA nanocarriers based on methacrylic acid copolymers.
J Control Release
; 152(1): 159-67, 2011 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195736
17.
Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA.
ACS Chem Biol
; 6(9): 912-9, 2011 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-21667942
18.
Chemical modification of siRNA.
Curr Protoc Nucleic Acid Chem
; Chapter 16: Unit 16.3, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20013783