Detalhe da pesquisa
1.
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance.
PLoS Pathog
; 18(2): e1010278, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35130315
2.
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548400
3.
Identification of Abundant and Evolutionarily Conserved Opioid Receptor Circular RNAs in the Nervous System Modulated by Morphine.
Mol Pharmacol
; 96(2): 247-258, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31243060
4.
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome.
Cell Chem Biol
; 30(5): 470-485.e6, 2023 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963402
5.
Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.
Lancet Infect Dis
; 22(6): 879-890, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35247321
6.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174
7.
Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.
Trends Parasitol
; 37(6): 476-492, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715941
8.
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.
J Med Chem
; 64(5): 2739-2761, 2021 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33620219
9.
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Elife
; 102021 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34279219
10.
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
J Med Chem
; 64(9): 6085-6136, 2021 05 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33876936