Detalhe da pesquisa
1.
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats.
J Med Chem
; 67(10): 7859-7869, 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38451215
2.
Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles.
Bioorg Med Chem Lett
; 20(16): 4753-6, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643548
3.
Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series.
Bioorg Med Chem Lett
; 20(22): 6802-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855212
4.
Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.
Bioorg Med Chem Lett
; 20(11): 3219-22, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457517
5.
Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.
Bioorg Med Chem Lett
; 20(5): 1674-6, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137937
6.
Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.
Bioorg Med Chem Lett
; 20(2): 704-8, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004099
7.
Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists.
Bioorg Med Chem Lett
; 20(6): 1830-3, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20176481
8.
Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists.
Bioorg Med Chem Lett
; 20(10): 3116-9, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20417098
9.
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist.
Bioorg Med Chem Lett
; 19(1): 209-13, 2009 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19014885
10.
Spiropiperidine CCR5 antagonists.
Bioorg Med Chem Lett
; 19(18): 5401-6, 2009 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19674898
11.
Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.
Nucleic Acids Res
; 31(23): 6852-9, 2003 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14627818
12.
The second extracellular loop of CCR5 contains the dominant epitopes for highly potent anti-human immunodeficiency virus monoclonal antibodies.
Antimicrob Agents Chemother
; 51(4): 1386-97, 2007 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-17242138
13.
CCR5 small-molecule antagonists and monoclonal antibodies exert potent synergistic antiviral effects by cobinding to the receptor.
Mol Pharmacol
; 72(1): 18-28, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17392523