Detalhe da pesquisa
1.
Exploring the Potential of Anthraquinone-Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH-Dependent Tumour.
Chemistry
; 29(62): e202302237, 2023 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37565343
2.
A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.
Neuropathol Appl Neurobiol
; 48(6): e12837, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35839783
3.
Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors.
Chemistry
; 27(32): 8350-8357, 2021 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811701
4.
A New Smoothened Antagonist Bearing the Purine Scaffold Shows Antitumour Activity In Vitro and In Vivo.
Int J Mol Sci
; 22(16)2021 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34445078
5.
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
EMBO J
; 35(13): 1400-16, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27234298
6.
Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects.
Am J Hum Genet
; 101(4): 552-563, 2017 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28965847
7.
P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation.
FASEB J
; 33(3): 4107-4123, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30526058
8.
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
EMBO J
; 34(2): 200-17, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25476449
9.
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma.
Cell Commun Signal
; 17(1): 108, 2019 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31455353
10.
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.
J Enzyme Inhib Med Chem
; 33(1): 349-358, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29338454
11.
microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1.
EMBO J
; 32(21): 2819-32, 2013 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24076654
12.
ß-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.
BMC Cancer
; 17(1): 488, 2017 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28716052
13.
Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy.
Biochim Biophys Acta
; 1856(1): 62-72, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26080084
14.
Hedgehog controls neural stem cells through p53-independent regulation of Nanog.
EMBO J
; 29(15): 2646-58, 2010 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20581804
15.
SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Cell Death Differ
; 31(2): 170-187, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38062245
16.
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination.
Nat Cell Biol
; 8(12): 1415-23, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17115028
17.
MFN2-dependent recruitment of ATAT1 coordinates mitochondria motility with alpha-tubulin acetylation and is disrupted in CMT2A.
bioRxiv
; 2023 Mar 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993604
18.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Cancer Lett
; 559: 216120, 2023 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893894
19.
Protected from the inside: endogenous histone deacetylase inhibitors and the road to cancer.
Biochim Biophys Acta
; 1815(2): 241-52, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21277938
20.
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells.
EMBO J
; 27(19): 2616-27, 2008 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18756266