Detalhe da pesquisa
1.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 184(18): 4651-4668.e25, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34450028
2.
Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Cell
; 187(6): 1565-1566, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38490183
3.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord
; 38(3): 386-398, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36807624
4.
Molecular determinants of the mechanism and substrate specificity of Clostridium difficile proline-proline endopeptidase-1.
J Biol Chem
; 294(30): 11525-11535, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182482
5.
Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients.
Int J Mol Sci
; 21(15)2020 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32707880
6.
MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats.
Toxicol Pathol
; 45(2): 353-361, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27565173
7.
Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective.
Regul Toxicol Pharmacol
; 87 Suppl 3: S1-S15, 2017 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28483710
8.
Functional genomics analysis reveals a MYC signature associated with a poor clinical prognosis in liposarcomas.
Am J Pathol
; 185(3): 717-28, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25622542
9.
Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice.
Toxicol Appl Pharmacol
; 300: 47-54, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27078884
10.
Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.
Chem Res Toxicol
; 29(4): 452-72, 2016 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26625186
11.
In Vitro Skin Models and Their Predictability in Defining Normal and Disease Biology, Pharmacology, and Toxicity.
Toxicol Pathol
; 44(4): 555-63, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26940714
12.
Tankyrase Inhibition Causes Reversible Intestinal Toxicity in Mice with a Therapeutic Index < 1.
Toxicol Pathol
; 44(2): 267-78, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26692561
13.
Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.
Chemistry
; 21(29): 10513-21, 2015 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26096911
14.
Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model.
Proc Natl Acad Sci U S A
; 109(51): 21052-7, 2012 Dec 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23213216
15.
Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors.
Toxicol Mech Methods
; 25(6): 478-86, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275124
16.
Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.
Toxicol Mech Methods
; 25(3): 201-11, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894564
17.
gem-Difluorocarbadisaccharides: restoring the exo-anomeric effect.
Angew Chem Int Ed Engl
; 53(36): 9597-602, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25044775
18.
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
Toxicol Appl Pharmacol
; 266(1): 86-94, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142475
19.
Prognostic value of metabolic parameters measured by first responders attending patients with severe trauma: associations with the New Injury Severity Score and mortality. / Valor pronóstico de los parámetros metabólicos medidos en la asistencia inicial a pacientes con trauma grave: asociación con la puntuación de la escala NISS y la mortalidad.
Emergencias
; 35(2): 90-96, 2023 04.
Artigo
em Inglês, Espanhol
| MEDLINE | ID: mdl-37038938
20.
[Esopheal foreign body impaction]. / Impactación de cuerpo extraño esofágico.
Acta Gastroenterol Latinoam
; 42(1): 46-9, 2012 Mar.
Artigo
em Espanhol
| MEDLINE | ID: mdl-22616497