Detalhe da pesquisa
1.
In vitro studies on a class of quinoline containing histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(11): 3295-300, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457525
2.
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
J Med Chem
; 51(5): 1231-41, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260617
3.
Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor.
J Med Chem
; 51(3): 380-3, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18183944
4.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
5.
Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.
Biochem Pharmacol
; 73(8): 1243-55, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17371699
6.
Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
J Med Chem
; 49(22): 6569-84, 2006 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064075
7.
Nonpeptide luteinizing hormone-releasing hormone antagonists derived from erythromycin A: design, synthesis, and biological activity of cladinose replacement analogues.
J Med Chem
; 47(5): 1085-97, 2004 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-14971889
8.
Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.
Eur J Pharmacol
; 435(1): 79-83, 2002 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-11790381
9.
The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
J Pharmacol Toxicol Methods
; 50(3): 187-99, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15519905
10.
Characterization of A-935142, a hERG enhancer, in the presence and absence of standard hERG blockers.
Life Sci
; 90(15-16): 607-11, 2012 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406079
11.
Pharmacological characterization of A-960656, a histamine H3 receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.
Eur J Pharmacol
; 684(1-3): 87-94, 2012 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22504024
12.
Ventricular rate adaptation: a novel, rapid, cellular-based in-vitro assay to identify proarrhythmic and torsadogenic compounds.
J Pharmacol Toxicol Methods
; 64(1): 68-73, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21440075
13.
Negative inotropic effect of a CB2 agonist A-955840 in isolated rabbit ventricular myocytes is independent of CB1 and CB2 receptors.
Curr Drug Saf
; 6(5): 277-84, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22424534
14.
A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current.
Biochem Pharmacol
; 80(7): 1000-6, 2010 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20599796
15.
Electrophysiologic characterization of a novel hERG channel activator.
Biochem Pharmacol
; 77(8): 1383-90, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19426677
16.
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists.
Bioorg Med Chem Lett
; 17(4): 874-8, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234405
17.
Identification of diamino chromone-2-carboxamides as MCHr1 antagonists with minimal hERG channel activity.
Bioorg Med Chem Lett
; 17(8): 2365-71, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17350253
18.
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Bioorg Med Chem Lett
; 17(4): 884-9, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17188866
19.
Caring for culturally diverse patients.
Nursing
; 23(10): 44-5, 1993 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-8414254