Detalhe da pesquisa
1.
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Bioorg Med Chem
; 26(4): 913-924, 2018 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29398441
2.
AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.
Blood
; 123(6): 905-13, 2014 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-24363397
3.
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
Proc Natl Acad Sci U S A
; 106(43): 18225-30, 2009 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19828435
4.
Structural basis for the catalytic mechanism of human phosphodiesterase 9.
Proc Natl Acad Sci U S A
; 105(36): 13309-14, 2008 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-18757755
5.
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma.
J Med Chem
; 62(21): 9918-9930, 2019 11 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31622099
6.
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J Med Chem
; 60(24): 10071-10091, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29172502
7.
Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.
Leuk Lymphoma
; 57(12): 2927-2929, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27189703