Detalhe da pesquisa
1.
Creation of a S1P Lyase bacterial surrogate for structure-based drug design.
Bioorg Med Chem Lett
; 26(9): 2293-6, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27013389
2.
Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors.
Bioorg Med Chem Lett
; 26(9): 2297-302, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020302
3.
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
Nature
; 435(7042): 677-81, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15902208
4.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
5.
Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.
J Med Chem
; 49(2): 656-63, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420051
6.
Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c]pyrazoles as multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 17(11): 3136-40, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17391959
7.
Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Bioorg Med Chem Lett
; 17(3): 750-5, 2007 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17110106
8.
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg Med Chem Lett
; 16(7): 2000-7, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16413780
9.
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of KDR kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4371-5, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16750628
10.
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 16(16): 4266-71, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16759855
11.
Parkinson's disease.
Curr Top Med Chem
; 9(10): 854, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19754399
12.
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Bioorg Med Chem Lett
; 12(21): 3077-9, 2002 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12372505
13.
Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.
Bioorg Med Chem Lett
; 14(3): 673-6, 2004 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741266