Detalhe da pesquisa
1.
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
BMC Struct Biol
; 12: 22, 2012 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22995073
2.
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.
Bioorg Med Chem Lett
; 20(1): 334-7, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19926477
3.
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.
Bioorg Med Chem Lett
; 20(1): 330-3, 2010 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19919896
4.
Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.
J Med Chem
; 50(14): 3283-9, 2007 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-17569517
5.
Alchemical free energy methods for drug discovery: progress and challenges.
Curr Opin Struct Biol
; 21(2): 150-60, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21349700
6.
Theoretical and experimental studies of biotin analogues that bind almost as tightly to streptavidin as biotin.
J Org Chem
; 67(6): 1827-37, 2002 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-11895399