Detalhe da pesquisa
1.
A Stereocontrolled Synthesis of a Phosphorothioate Cyclic Dinucleotide-Based STING Agonist.
J Org Chem
; 86(13): 8851-8861, 2021 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126006
2.
Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8).
ACS Med Chem Lett
; 13(5): 812-818, 2022 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35586440
3.
Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design.
J Med Chem
; 64(19): 14247-14265, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34543572
4.
Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9).
ACS Med Chem Lett
; 11(9): 1751-1758, 2020 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32944143
5.
Preparation of 2,7-diaminosubstituted-[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitriles by solid-phase synthesis.
J Comb Chem
; 10(1): 28-30, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-17994705
6.
Solid phase synthesis of 1,5-diarylpyrazole-4-carboxamides: discovery of antagonists of the CB-1 receptor.
ACS Comb Sci
; 14(3): 197-204, 2012 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22340081
7.
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
J Med Chem
; 53(9): 3814-30, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20405922
8.
Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.
Bioorg Med Chem Lett
; 17(7): 1908-11, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17291752
9.
Solid-phase synthesis of 5-substituted amino pyrazoles.
J Comb Chem
; 7(4): 584-8, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16004502