RESUMO
Implants are now the standard method of replacing missing or damaged teeth. Despite the improving technologies for the manufacture of implants and the introduction of new protocols for diagnosing, planning, and performing implant placement operations, the percentage of complications in the early postoperative period remains quite high. In this regard, there is a need to develop new methods for preliminary assessment of the patient's condition to predict the success of single implant survival. The intensive development of artificial intelligence technologies and the increase in the amount of digital information that is available for analysis make it relevant to develop systems based on neural networks for auxiliary diagnostics and forecasting. Systems based on artificial intelligence in the field of dental implantology can become one of the methods for forming a second opinion based on mathematical decision making and forecasting. The actual clinical evaluation of a particular case and further treatment are carried out by the dentist, and AI-based systems can become an integral part of additional diagnostics. The article proposes an artificial intelligence system for analyzing various patient statistics to predict the success of single implant survival. As the topology of the neural network, the most optimal linear neural network architectures were developed. The one-hot encoding method was used as a preprocessing method for statistical data. The novelty of the proposed system lies in the developed optimal neural network architecture designed to recognize the collected and digitized database of various patient factors based on the description of the case histories. The accuracy of recognition of statistical factors of patients for predicting the success of single implants in the proposed system was 94.48%. The proposed neural network system makes it possible to achieve higher recognition accuracy than similar neural network prediction systems due to the analysis of a large number of statistical factors of patients. The use of the proposed system based on artificial intelligence will allow the implantologist to pay attention to the insignificant factors affecting the quality of the installation and the further survival of the implant, and reduce the percentage of complications at all stages of treatment. However, the developed system is not a medical device and cannot independently diagnose patients. At this point, the neural network system for analyzing the statistical factors of patients can predict a positive or negative outcome of a single dental implant operation and cannot be used as a full-fledged tool for supporting medical decision-making.
RESUMO
Finding new, safe strategies to prevent and control rheumatoid arthritis is an urgent task. Bioactive peptides and peptide-rich protein hydrolyzate represent a new trend in the development of functional foods and nutraceuticals. The resulting tissue hydrolyzate of the chicken embryo (CETH) has been evaluated for acute toxicity and tested against chronic arthritis induced by Freund's full adjuvant (modified Mycobacterium butyricum) in rats. The antiarthritic effect of CETH was studied on the 28th day of the experiment after 2 weeks of oral administration of CETH at doses of 60 and 120 mg/kg body weight. Arthritis was evaluated on the last day of the experiment on the injected animal paw using X-ray computerized microtomography and histopathology analysis methods. The CETH effect was compared with the non-steroidal anti-inflammatory drug diclofenac sodium (5 mg/kg). Oral administration of CETH was accompanied by effective dose-dependent correction of morphological changes caused by the adjuvant injection. CETH had relatively high recovery effects in terms of parameters for reducing inflammation, inhibition of osteolysis, reduction in the inflammatory reaction of periarticular tissues, and cartilage degeneration. This study presents for the first time that CETH may be a powerful potential nutraceutical agent or bioactive component in the treatment of rheumatoid arthritis.