Detalhe da pesquisa
1.
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective.
Xenobiotica
; 53(8-9): 547-558, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37880944
2.
Examination of the Human Cytochrome P4503A4 Induction Potential of PF-06282999, an Irreversible Myeloperoxidase Inactivator: Integration of Preclinical, In Silico, and Biomarker Methodologies in the Prediction of the Clinical Outcome.
Drug Metab Dispos
; 45(5): 501-511, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28254951
3.
Once-weekly administration of a long-acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non-human primates.
Diabetes Obes Metab
; 19(12): 1762-1772, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28573777
4.
Non-canonical inflammasome activation targets caspase-11.
Nature
; 479(7371): 117-21, 2011 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22002608
5.
Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.
Drug Metab Dispos
; 44(2): 209-19, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26608081
6.
Pharmacokinetics and pharmacodynamics of PF-05231023, a novel long-acting FGF21 mimetic, in a first-in-human study.
Br J Clin Pharmacol
; 80(5): 1051-63, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25940675
7.
Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish.
Dev Dyn
; 243(10): 1275-85, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24677486
8.
Implementation of whole-exome sequencing for pharmacogenomics profiling and exploring its potential clinical utilities.
Pharmacogenomics
; 25(4): 197-206, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38511470
9.
Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma.
Clin Transl Sci
; 17(3): e13730, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38411318
10.
Asia-Inclusive Global Development of Enpatoran: Results of an Ethno-Bridging Study, Intrinsic/Extrinsic Factor Assessments and Disease Trajectory Modeling to Inform Design of a Phase II Multiregional Clinical Trial.
Clin Pharmacol Ther
; 115(6): 1346-1357, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38415785
11.
Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo): genome assembly and analysis.
PLoS Biol
; 8(9)2010 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20838655
12.
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis.
Proc Natl Acad Sci U S A
; 107(21): 9771-6, 2010 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457908
13.
Alternatives to rifampicin: A review and perspectives on the choice of strong CYP3A inducers for clinical drug-drug interaction studies.
Clin Transl Sci
; 15(9): 2075-2095, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35722783
14.
Risk assessment of drug-drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach.
Clin Transl Sci
; 15(12): 2838-2843, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36152313
15.
Applying Modeling and Simulations for Rational Dose Selection of Novel Toll-Like Receptor 7/8 Inhibitor Enpatoran for Indications of High Medical Need.
Clin Pharmacol Ther
; 112(2): 297-306, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35390178
16.
Exposure-response analyses for the MET inhibitor tepotinib including patients in the pivotal VISION trial: support for dosage recommendations.
Cancer Chemother Pharmacol
; 90(1): 53-69, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35771259
17.
A phase 1b study evaluating the safety and preliminary efficacy of berzosertib in combination with gemcitabine in patients with advanced non-small cell lung cancer.
Lung Cancer
; 163: 19-26, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894455
18.
Phase 1b study of berzosertib and cisplatin in patients with advanced triple-negative breast cancer.
NPJ Breast Cancer
; 8(1): 45, 2022 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393425
19.
A comparative physical map reveals the pattern of chromosomal evolution between the turkey (Meleagris gallopavo) and chicken (Gallus gallus) genomes.
BMC Genomics
; 12: 447, 2011 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21906286
20.
Evobrutinib, a covalent Bruton's tyrosine kinase inhibitor: Mass balance, elimination route, and metabolism in healthy participants.
Clin Transl Sci
; 14(6): 2420-2430, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34374206