Detalhe da pesquisa
1.
Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
Br J Clin Pharmacol
; 88(1): 128-137, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075612
2.
Malaria - Epidemiology, Treatment, and Prevention.
N Engl J Med
; 388(5): e9, 2023 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36724327
3.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
Clin Infect Dis
; 71(10): e657-e664, 2020 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239164
4.
Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932368
5.
Monoclonal Antibodies for Malaria.
N Engl J Med
; 387(5): 462-465, 2022 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35921457
6.
First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.
Br J Clin Pharmacol
; 86(6): 1113-1124, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31925817
7.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
8.
Carbon-14 radiolabeling and tissue distribution evaluation of MMV390048.
J Labelled Comp Radiopharm
; 59(14): 680-688, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27646069
9.
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Antimicrob Agents Chemother
; 59(9): 5555-60, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26124159
10.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
11.
Efficacy, Safety, Tolerability, and Pharmacokinetics of MMV390048 in Acute Uncomplicated Malaria.
Am J Trop Med Hyg
; 108(1): 81-84, 2023 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36509063
12.
Malarial PI4K inhibitor induced diaphragmatic hernias in rat: Potential link with mammalian kinase inhibition.
Birth Defects Res
; 114(10): 487-498, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35416431
13.
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
Am J Trop Med Hyg
; 104(4): 1348-1358, 2021 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33556040
14.
Discovery of a novel series of potent S1P1 agonists.
Bioorg Med Chem Lett
; 20(5): 1516-9, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149651
15.
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.
Sci Transl Med
; 9(387)2017 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446690