Detalhe da pesquisa
1.
Discovery of fluorobenzimidazole HCV NS5A inhibitors.
Bioorg Med Chem Lett
; 26(22): 5462-5467, 2016 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27780635
2.
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
J Med Chem
; 67(8): 6456-6494, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38574366
3.
High potency improvements to weak aryl uracil HCV polymerase inhibitor leads.
Bioorg Med Chem Lett
; 23(15): 4367-9, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23791079
4.
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif.
Bioorg Med Chem Lett
; 23(12): 3487-90, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664214
5.
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Bioorg Med Chem Lett
; 21(6): 1876-9, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316235
6.
Des-A-ring benzothiadiazines: inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase.
Bioorg Med Chem Lett
; 18(8): 2735-8, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362072
7.
Identification of halosalicylamide derivatives as a novel class of allosteric inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 18(11): 3173-7, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18479921
8.
Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315.
J Med Chem
; 61(15): 6647-6657, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004704
9.
Synthesis and Biological Characterization of Aryl Uracil Inhibitors of Hepatitis C Virus NS5B Polymerase: Discovery of ABT-072, a trans-Stilbene Analog with Good Oral Bioavailability.
J Med Chem
; 61(3): 1153-1163, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342358
10.
Highlights of the Structure-Activity Relationships of Benzimidazole Linked Pyrrolidines Leading to the Discovery of the Hepatitis C Virus NS5A Inhibitor Pibrentasvir (ABT-530).
J Med Chem
; 61(9): 4052-4066, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29653491
11.
Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
J Med Chem
; 57(5): 2047-57, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24400777
12.
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines.
Bioorg Med Chem Lett
; 15(6): 1577-82, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15745800