Toward the development of a feature-space representation for a complex natural category domain.

This article reports data sets aimed at the development of a detailed feature-space representation for a complex natural category domain, namely 30 common subtypes of the categories of igneous, metamorphic, and sedimentary rocks. We conducted web searches to develop a library of 12 tokens each of the 30 subtypes, for a total of 360 rock pictures. In one study, subjects provided ratings along a set of 18 hypothesized primary dimensions involving visual characteristics of the rocks. In other studies, subjects provided similarity judgments among pairs of the rock tokens. Analyses are reported to validate the regularity and information value of the dimension ratings. In addition, analyses are reported that derive psychological scaling solutions from the similarity-ratings data and that interrelate the derived dimensions of the scaling solutions with the directly rated dimensions of the rocks. The stimulus set and various forms of ratings data, as well as the psychological scaling solutions, are made available on an online website (https://osf.io/w64fv/) associated with the article. The study provides a fundamental data set that should be of value for a wide variety of research purposes, including: (1) probing the statistical and psychological structure of a complex natural category domain, (2) testing models of similarity judgment, and (3) developing a feature-space representation that can be used in combination with formal models of category learning to predict classification performance in this complex natural category domain.

On Learning Natural-Science Categories That Violate the Family-Resemblance Principle.

The general view in psychological science is that natural categories obey a coherent, family-resemblance principle. In this investigation, we documented an example of an important exception to this principle: Results of a multidimensional-scaling study of igneous, metamorphic, and sedimentary rocks (Experiment 1) suggested that the structure of these categories is disorganized and dispersed. This finding motivated us to explore what might be the optimal procedures for teaching dispersed categories, a goal that is likely critical to science education in general. Subjects in Experiment 2 learned to classify pictures of rocks into compact or dispersed high-level categories. One group learned the categories through focused high-level training, whereas a second group was required to simultaneously learn classifications at a subtype level. Although high-level training led to enhanced performance when the categories were compact, subtype training was better when the categories were dispersed. We provide an interpretation of the results in terms of an exemplar-memory model of category learning.

First Report of Gender Based Violence as a Deterrent to Methadone Access Among Females Who Use Heroin in Dar es Salaam, Tanzania.

High prevalence of human immunodeficiency virus (HIV) among females who use drugs in Dar es Salaam, Tanzania, contrasts strikingly with their low enrollment in HIV risk reduction services such as methadone assisted therapy (MAT). We conducted a case-control study to examine factors associated with non-enrollment in MAT, with a focus on gender-based violence. We interviewed 202 female heroin users not enrolled in MAT as cases and 93 females enrolled in MAT. We fitted logistic regression models with MAT enrollment as the outcome of interest. The likelihood of MAT enrollment decreased upon being in a violent relationship [odds ratio (OR) 0.23; 95 % CI 0.11-0.40], with experience of discrimination by a healthcare provider (OR 0.11; 95 % CI 0.04-0.35), and having a partner who also uses drugs (OR 0.05; 95 % CI 0.01-0.26). The results indicate that violence and discrimination are major impediments to MAT enrollment, necessitating implementation of interventions to address them.

Pharmacokinetic interactions between buprenorphine/naloxone and raltegravir in subjects receiving chronic buprenorphine/naloxone treatment.

BACKGROUND: Interactions between human immuno-deficiency virus (HIV) and opioid-dependence therapies can occur. OBJECTIVES: We sought to determine whether such interactions occurred between buprenorphine/naloxone and raltegravir. METHODS: We performed a within-subject open-labeled pharmacokinetic and pharmacodynamic study in 12 HIV-seronegative subjects stabilized on at least 3 weeks of buprenorphine/naloxone therapy. Subjects underwent baseline and steady-state evaluation of the effect of raltegravir 400 mg BID on buprenorphine/naloxone parameters. RESULTS: Compared with baseline values, buprenorphine AUC(0-24 h) (58.2 vs. 56.0 hr*ng/mL) and C(max) (7.37 vs. 6.60 ng/mL) did not differ significantly after achieving steady-state raltegravir. Similar analyses of norbuprenorphine, the primary metabolite of buprenorphine, demonstrated no significant difference after raltegravir administration. Naloxone concentrations were unchanged for AUC(0-24 h) (.595 vs. .581 hr*ng/mL), C(max) (.251 vs. .243 ng/mL) and T(max) (.75 vs.1.08 h). Objective opioid withdrawal was not observed. The AUC(0-12 h) and C(max) of raltegravir did not significantly differ from historical controls (5543 vs. 4428 h*ng/mL and 1070 vs. 1266 ng/mL), respectively. CONCLUSION: The addition of raltegravir to stabilized patients receiving buprenorphine/naloxone does not significantly affect buprenorphine/naloxone or raltegravir pharmacokinetic or pharmacodynamic parameters.

Where are the RNA vaccines for TB?

A simple mRNA vaccine was shown to protect mice against tuberculosis more than 15 years ago. Like COVID-19, tuberculosis is a respiratory infection killing over a million people per year. It too presents a global emergency. Can the stunning success of RNA vaccination against COVID-19 be replicated for TB?

Mass and volume contributions to twentieth-century global sea level rise.

The rate of twentieth-century global sea level rise and its causes are the subjects of intense controversy. Most direct estimates from tide gauges give 1.5-2.0 mm yr(-1), whereas indirect estimates based on the two processes responsible for global sea level rise, namely mass and volume change, fall far below this range. Estimates of the volume increase due to ocean warming give a rate of about 0.5 mm yr(-1) (ref. 8) and the rate due to mass increase, primarily from the melting of continental ice, is thought to be even smaller. Therefore, either the tide gauge estimates are too high, as has been suggested recently, or one (or both) of the mass and volume estimates is too low. Here we present an analysis of sea level measurements at tide gauges combined with observations of temperature and salinity in the Pacific and Atlantic oceans close to the gauges. We find that gauge-determined rates of sea level rise, which encompass both mass and volume changes, are two to three times higher than the rates due to volume change derived from temperature and salinity data. Our analysis supports earlier studies that put the twentieth-century rate in the 1.5-2.0 mm yr(-1) range, but more importantly it suggests that mass increase plays a larger role than ocean warming in twentieth-century global sea level rise.

The occupational therapy practitioner's role in health promotion, injury prevention, and role participation for the older worker.

As the population of individuals aged sixty-five and older continues to grow, the number of older individuals participating in the workforce rises alongside, with projections estimating as many as 72 million older workers by 2030. Due to this rapid increase in the number of older workers, new challenges to worker health and to health-related productivity will arise in the coming years. Occupational therapy practitioners are uniquely suited to address many of these challenges given their background in activity analysis, assessment and modification of job demands, health promotion and successful aging. However, there is need for continued research in this area to expand the role of the occupational therapy practitioner in prevention and return-to-work interventions focused on the older worker, and to advocate for the value occupational therapy practitioners can contribute to this field.

Selection of Reference Genes for Expression Studies of Xenobiotic Adaptation in Tetranychus urticae.

Quantitative real-time PCR (qRT-PCR) is an extensively used, high-throughput method to analyze transcriptional expression of genes of interest. An appropriate normalization strategy with reliable reference genes is required for calculating gene expression across diverse experimental conditions. In this study, we aim to identify the most stable reference genes for expression studies of xenobiotic adaptation in Tetranychus urticae, an extremely polyphagous herbivore causing significant yield reduction of agriculture. We chose eight commonly used housekeeping genes as candidates. The qRT-PCR expression data for these genes were evaluated from seven populations: a susceptible and three acaricide resistant populations feeding on lima beans, and three other susceptible populations which had been shifted host from lima beans to three other plant species. The stability of the candidate reference genes was then assessed using four different algorithms (comparative ΔCt method, geNorm, NormFinder, and BestKeeper). Additionally, we used an online web-based tool (RefFinder) to assign an overall final rank for each candidate gene. Our study found that CycA and Rp49 are best for investigating gene expression in acaricide susceptible and resistant populations. GAPDH, Rp49, and Rpl18 are best for host plant shift studies. And GAPDH and Rp49 were the most stable reference genes when investigating gene expression under changes in both experimental conditions. These results will facilitate research in revealing molecular mechanisms underlying the xenobiotic adaptation of this notorious agricultural pest.

Evaluating patients' perception of service quality at hospitals in nine Chinese cities by use of the ServQual scale

Objective: To investigate patients' perception of service quality at hospitals in nine Chinese cities and propose some measures for improvement. Methods: The ServQual scale method was used in a survey involving patients at outpatient and in-patient facilities in Shanghai, Chongqing, Chengdu, Nanning, Guilin and Laibin of Guangxi, Honghezhou of Yunnan, Wulumuqi of Xinjiang and Zhongshan of Guangdong. The data collected were entered and analyzed using SPSS 20.0. Statistical analyses included descriptive statistics, factor analyses, reliability analyses, productmoment correlations, independent-sample t-tests, One-way ANOVA and regression analyses. Results: The Kaiser-Meyer-Olkin value for the factor analysis of the scale was 0.979. The Cronbach's α for the reliability analysis was 0.978. All the Pearson correlation coefficients were positive and statistically significant. Visitors to out-patient facilities reported more positive perception than visitors to in-patient facilities on tangibles (t = 4.168, P < 0.001) and reliability (t = 1.979, P < 0.05). Patients of 60 years of age and above reported more positive perception than those between 40 and 49 on reliability (F = 3.311, P = 0.010), assurances (F = 2.751, P < 0.05) and empathy (F = 4.009, P = 0.003). For the five dimensions of the scale, patients in Laibin, Guangxi reported the most positive perceived service quality, followed by patients in Shanghai. On the other hand, patients in Chongqing and Nanning and Guilin of Guangxi reported relatively poor perceptions of service quality. Standardized regression coefficients showed statistically significant (P < 0.001) positive values for all ServQual dimensions. Empathy (β = 0.267) and reliability (β = 0.239) most strongly predicted perception of service quality. Conclusions: Chinese patients perceived service quality as satisfactory. Hospitals in various regions of China should enhance their awareness and ability to serve their patients.

On the rate and causes of twentieth century sea-level rise.

Both the rate and causes of twentieth century global sea-level rise (GSLR) have been controversial. Estimates from tide-gauges range from less than one, to more than two millimetre yr(-1). In contrast, values based on the processes mostly responsible for GSLR-mass increase (from mountain glaciers and the great high latitude ice masses) and volume increase (expansion due to ocean warming)-fall below this range. Either the gauge estimates are too high, or one (or both) of the component estimates is too low. Gauge estimates of GSLR have been in dispute for several decades because of vertical land movements, especially due to glacial isostatic adjustment (GIA). More recently, the possibility has been raised that coastal tide-gauges measure exaggerated rates of sea-level rise because of localized ocean warming. Presented here are two approaches to a resolution of these problems. The first is morphological, based on the limiting values of observed trends of twentieth century relative sea-level rise as a function of distance from the centres of the ice loads at last glacial maximum. This observational approach, which does not depend on a geophysical model of GIA, supports values of GSLR near 2 mm yr(-1). The second approach involves an analysis of long records of tide-gauge and hydrographic (in situ temperature and salinity) observations in the Pacific and Atlantic Oceans. It was found that sea-level trends from tide-gauges, which reflect both mass and volume change, are 2-3 times higher than rates based on hydrographic data which reveal only volume change. These results support those studies that put the twentieth century rate near 2 mm yr(-1), thereby indicating that mass increase plays a much larger role than ocean warming in twentieth century GSLR.

Evaluation of irreversible JPEG compression for a clinical ultrasound practice.

A prior ultrasound study indicated that images with low to moderate levels of JPEG and wavelet compression were acceptable for diagnostic purposes. The purpose of this study is to validate this prior finding using the Joint Photographic Experts Group (JPEG) baseline compression algorithm, at a compression ratio of approximately 10:1, on a sufficiently large number of grayscale and color ultrasound images to attain a statistically significant result. The practical goal of this study is to determine if it is feasible for radiologists to use irreversibly compressed images as an integral part of the day to day ultrasound practice (ie, perform primary diagnosis with, and store irreversibly compressed images in the ultrasound PACS archive). In this study, 5 Radiologists were asked to review 300 grayscale and color static ultrasound images selected from 4 major anatomic groups. Each image was compressed and decompressed using the JPEG baseline compression algorithm at a fixed quality factor resulting in an average compression ratio of approximately 9:1. The images were presented in pairs (original and compressed) in a blinded fashion on a PACS workstation in the ultrasound reading areas, and radiologists were asked to pick which image they preferred in terms of diagnostic utility and their degree of certainty (on a scale from 1 to 4). Of the 1499 total readings, 50.17% (95% confidence intervals at 47.6%, and 52.7%) indicated a preference for the original image in the pair, and 49.83% (95% confidence intervals at 47.3%, and 52.0%) indicated a preference for the compressed image. These findings led the authors to conclude that static color and gray-scale ultrasound images compressed with JPEG at approximately 9:1 are statistically indistinguishable from the originals for primary diagnostic purposes. Based on the authors laboratory experience with compression and the results of this and other prior studies, JPEG compression is now being applied to all ultrasound images in the authors' radiology practice before reading. No image quality-related issues have been encountered after 12 months of operation (approximately 48000 examinations).

Extraction of nonlinear hysteretic properties of seismically isolated bridges from quick - release field tests

A time domian system identification method is used to identify the hysteretic properties of lead-rubber bearings installed in seismically isolated bridge systems. The longitudinal or transverse motion of the superstructure is idealized as a single degree of freedom (SDOF) system, where the total damping effect has been divided two parts.