Pesquisa | Biblioteca Virtual em Saúde

1.

Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.

Rodríguez-Martínez, Marta; Boissiére, Thierry; Noe Gonzalez, Melvin; Litchfield, Kevin; Mitter, Richard; Walker, Jane; KjÅr, Svend; Ismail, Mohamed; Downward, Julian; Swanton, Charles; Svejstrup, Jesper Q.

Cell ; 181(6): 1395-1405.e11, 2020 06 11.

Artigo em Inglês | MEDLINE | ID: mdl-32531245

2.

Mutant KRAS at the Heart of Tumor Immune Evasion.

van Maldegem, Febe; Downward, Julian.

Immunity ; 52(1): 14-16, 2020 01 14.

Artigo em Inglês | MEDLINE | ID: mdl-31951548

3.

Antibodies against endogenous retroviruses promote lung cancer immunotherapy.

Ng, Kevin W; Boumelha, Jesse; Enfield, Katey S S; Almagro, Jorge; Cha, Hongui; Pich, Oriol; Karasaki, Takahiro; Moore, David A; Salgado, Roberto; Sivakumar, Monica; Young, George; Molina-Arcas, Miriam; de Carné Trécesson, Sophie; Anastasiou, Panayiotis; Fendler, Annika; Au, Lewis; Shepherd, Scott T C; Martínez-Ruiz, Carlos; Puttick, Clare; Black, James R M; Watkins, Thomas B K; Kim, Hyemin; Shim, Seohee; Faulkner, Nikhil; Attig, Jan; Veeriah, Selvaraju; Magno, Neil; Ward, Sophia; Frankell, Alexander M; Al Bakir, Maise; Lim, Emilia L; Hill, Mark S; Wilson, Gareth A; Cook, Daniel E; Birkbak, Nicolai J; Behrens, Axel; Yousaf, Nadia; Popat, Sanjay; Hackshaw, Allan; Hiley, Crispin T; Litchfield, Kevin; McGranahan, Nicholas; Jamal-Hanjani, Mariam; Larkin, James; Lee, Se-Hoon; Turajlic, Samra; Swanton, Charles; Downward, Julian; Kassiotis, George.

Nature ; 616(7957): 563-573, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-37046094

4.

RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.

Fritsch, Ralph; de Krijger, Inge; Fritsch, Kornelia; George, Roger; Reason, Beth; Kumar, Madhu S; Diefenbacher, Markus; Stamp, Gordon; Downward, Julian.

Cell ; 153(5): 1050-63, 2013 May 23.

Artigo em Inglês | MEDLINE | ID: mdl-23706742

5.

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.

Kumar, Madhu S; Hancock, David C; Molina-Arcas, Miriam; Steckel, Michael; East, Phillip; Diefenbacher, Markus; Armenteros-Monterroso, Elena; Lassailly, François; Matthews, Nik; Nye, Emma; Stamp, Gordon; Behrens, Axel; Downward, Julian.

Cell ; 149(3): 642-55, 2012 Apr 27.

Artigo em Inglês | MEDLINE | ID: mdl-22541434

6.

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

Coelho, Matthew A; de Carné Trécesson, Sophie; Rana, Sareena; Zecchin, Davide; Moore, Christopher; Molina-Arcas, Miriam; East, Philip; Spencer-Dene, Bradley; Nye, Emma; Barnouin, Karin; Snijders, Ambrosius P; Lai, Wi S; Blackshear, Perry J; Downward, Julian.

Immunity ; 47(6): 1083-1099.e6, 2017 12 19.

Artigo em Inglês | MEDLINE | ID: mdl-29246442

7.

SnapShot: Class I PI3K isoform signaling.

Fritsch, Ralph; Downward, Julian.

Cell ; 154(4): 940-940.e1, 2013 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-23953121

8.

Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis.

Yao, Liudi; Zhou, Yilu; Li, Juanjuan; Wickens, Leanne; Conforti, Franco; Rattu, Anna; Ibrahim, Fathima Maneesha; Alzetani, Aiman; Marshall, Ben G; Fletcher, Sophie V; Hancock, David; Wallis, Tim; Downward, Julian; Ewing, Rob M; Richeldi, Luca; Skipp, Paul; Davies, Donna E; Jones, Mark G; Wang, Yihua.

J Biol Chem ; 297(3): 101096, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34418430

9.

Inherited duplications of PPP2R3B predispose to nevi and melanoma via a C21orf91-driven proliferative phenotype.

Polubothu, Satyamaanasa; Zecchin, Davide; Al-Olabi, Lara; Lionarons, Daniël A; Harland, Mark; Horswell, Stuart; Thomas, Anna C; Hunt, Lilian; Wlodarchak, Nathan; Aguilera, Paula; Brand, Sarah; Bryant, Dale; Carrera, Cristina; Chen, Hui; Elgar, Greg; Harwood, Catherine A; Howell, Michael; Larue, Lionel; Loughlin, Sam; MacDonald, Jeff; Malvehy, Josep; Barberan, Sara Martin; da Silva, Vanessa Martins; Molina, Miriam; Morrogh, Deborah; Moulding, Dale; Nsengimana, Jérémie; Pittman, Alan; Puig-Butillé, Joan-Anton; Parmar, Kiran; Sebire, Neil J; Scherer, Stephen; Stadnik, Paulina; Stanier, Philip; Tell, Gemma; Waelchli, Regula; Zarrei, Mehdi; Puig, Susana; Bataille, Véronique; Xing, Yongna; Healy, Eugene; Moore, Gudrun E; Di, Wei-Li; Newton-Bishop, Julia; Downward, Julian; Kinsler, Veronica A.

Genet Med ; 23(9): 1636-1647, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34145395

10.

The Potency of a KRAS Silent Variant.

Molina-Arcas, Miriam; Downward, Julian.

N Engl J Med ; 386(26): 2523-2525, 2022 06 30.

Artigo em Inglês | MEDLINE | ID: mdl-35767444

11.

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.

Kumar, Madhu S; Armenteros-Monterroso, Elena; East, Philip; Chakravorty, Probir; Matthews, Nik; Winslow, Monte M; Downward, Julian.

Nature ; 505(7482): 212-7, 2014 Jan 09.

Artigo em Inglês | MEDLINE | ID: mdl-24305048

12.

Flicking the Warburg switch-tyrosine phosphorylation of pyruvate dehydrogenase kinase regulates mitochondrial activity in cancer cells.

Schulze, Almut; Downward, Julian.

Mol Cell ; 44(6): 846-8, 2011 Dec 23.

Artigo em Inglês | MEDLINE | ID: mdl-22195959

13.

Michael D. Waterfield.

Downward, Julian; Parker, Peter J; Vanhaesebroeck, Bart.

Biochem J ; 480(18): 1475-1478, 2023 Sep 27.

Artigo em Inglês | MEDLINE | ID: mdl-37732645

14.

Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.

Mathew, Grinu; Hannan, Abdul; Hertzler-Schaefer, Kristina; Wang, Fen; Feng, Gen-Sheng; Zhong, Jian; Zhao, Jean J; Downward, Julian; Zhang, Xin.

Proc Natl Acad Sci U S A ; 113(46): 13156-13161, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27799550

15.

SnapShot: Ras Signaling.

Cully, Megan; Downward, Julian.

Cell ; 133(7): 1292-1292.e1, 2008 Jun 27.

Artigo em Inglês | MEDLINE | ID: mdl-18585361

16.

PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death.

Gandhi, Sonia; Wood-Kaczmar, Alison; Yao, Zhi; Plun-Favreau, Helene; Deas, Emma; Klupsch, Kristina; Downward, Julian; Latchman, David S; Tabrizi, Sarah J; Wood, Nicholas W; Duchen, Michael R; Abramov, Andrey Y.

Mol Cell ; 33(5): 627-38, 2009 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-19285945

17.

Unraveling the complexity of endocrine resistance in breast cancer by functional genomics.

Swanton, Charles; Downward, Julian.

Cancer Cell ; 13(2): 83-5, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18242507

18.

YAP and p73: a complex affair.

Downward, Julian; Basu, Subham.

Mol Cell ; 32(6): 749-50, 2008 Dec 26.

Artigo em Inglês | MEDLINE | ID: mdl-19111652

19.

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.

Raz, Richard; Burlina, Fabienne; Ismail, Mohamed; Downward, Julian; Li, Jiejin; Smerdon, Stephen J; Quibell, Martin; White, Peter D; Offer, John.

Angew Chem Int Ed Engl ; 55(42): 13174-13179, 2016 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-27654901

20.

Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gerlinger, Marco; Rowan, Andrew J; Horswell, Stuart; Math, M; Larkin, James; Endesfelder, David; Gronroos, Eva; Martinez, Pierre; Matthews, Nicholas; Stewart, Aengus; Tarpey, Patrick; Varela, Ignacio; Phillimore, Benjamin; Begum, Sharmin; McDonald, Neil Q; Butler, Adam; Jones, David; Raine, Keiran; Latimer, Calli; Santos, Claudio R; Nohadani, Mahrokh; Eklund, Aron C; Spencer-Dene, Bradley; Clark, Graham; Pickering, Lisa; Stamp, Gordon; Gore, Martin; Szallasi, Zoltan; Downward, Julian; Futreal, P Andrew; Swanton, Charles.

N Engl J Med ; 366(10): 883-892, 2012 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-22397650

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