It is Not (Always) the Mismatch That Beats You-On the Relationship Between Interaction of Early and Recent Life Stress and Emotion Regulation, an fMRI Study.

Stress may impact the ability to effectively regulate emotions. To study the impact of stressful experiences in early and recent life on emotion regulation, we examined the relationship between early life stress, recent stress, and brain activation during cognitive reappraisal. We investigated two regulation goals: the decrease and increase of emotional response to both negative and positive stimuli. Furthermore, two models of stress consequences were examined: the cumulative and match/mismatch models. A total of 83 participants (Mage = 21.66) took part in the study. There was an interaction between cumulative stress and stimuli valence in the cuneus, superior lateral occipital cortex, superior parietal lobule, supramarginal gyrus extending to superior temporal gyrus, and precentral gyrus extending to supplementary motor area. Interaction between mismatched stress index and stimuli valence was found in the left hippocampus, left insula extending to the orbitofrontal cortex and amygdala, and in a cluster including the anterior cingulate cortex, superior frontal gyrus, and frontal pole. Furthermore, there were differences between the effects of cumulative and mismatched stress indices on brain activation during reappraisal of positive but not negative stimuli. Results indicate that cumulative stress and match/mismatch approaches are both useful for explaining brain activation during reappraisal. This finding is important for our understanding of the multifaceted impact of stress on emotion regulation.

Childhood Gender Nonconformity and Recalled Perceived Parental and Peer Acceptance Thereof, Internalized Homophobia, and Psychological Well-Being Outcomes in Heterosexual and Gay Men from Poland.

The link between gender nonconformity and psychopathology may be due in part to negative childhood experiences resulting from other people's reactions to gender nonconformity. The aim of this study was to test whether recalled perceived levels of parental and peer acceptance of childhood gender nonconforming behaviors and play mediate the relationship of childhood gender nonconformity with depression and social anxiety in adulthood. We also tested whether this relationship was moderated by sexual orientation and, among gay men, whether internalized homophobia was an additional mediator. All variables were measured in a large sample of male participants using self-report (n = 449 gay men, age: M = 27.8 years, SD = 6.69; and n = 296 heterosexual men, age: M = 27.4 years, SD = 6.57) in Poland. Gay men reported more childhood gender nonconformity than heterosexual men. The relationship between gender nonconformity and depressive symptoms as well as social anxiety symptoms was significant in both gay and heterosexual men. Among gay men, this relationship was partially mediated by peer but not parental acceptance of the measured aspects of gender nonconformity and internalized homophobia. Among heterosexual men, recalled perceived parental acceptance of gender nonconformity partially mediated the relationship between gender nonconformity and depressive and social anxiety symptoms. Our findings were partially in line with those found in Western European and North American samples. Although the two groups differed in their recalled perceived gender nonconformity, they did not differ in their depression or social anxiety scores. Nevertheless, childhood gender nonconformity may be an indirect risk associated with mental health symptoms, irrespective of sexual orientation. Its higher prevalence among nonheterosexual individuals makes it a particular risk for this group.

The relationship between early and recent life stress and emotional expression processing: A functional connectivity study.

The aim of this study was to characterize neural activation during the processing of negative facial expressions in a non-clinical group of individuals characterized by two factors: the levels of stress experienced in early life and in adulthood. Two models of stress consequences were investigated: the match/mismatch and cumulative stress models. The match/mismatch model assumes that early adversities may promote optimal coping with similar events in the future through fostering the development of coping strategies. The cumulative stress model assumes that effects of stress are additive, regardless of the timing of the stressors. Previous studies suggested that stress can have both cumulative and match/mismatch effects on brain structure and functioning and, consequently, we hypothesized that effects on brain circuitry would be found for both models. We anticipated effects on the neural circuitry of structures engaged in face perception and emotional processing. Hence, the amygdala, fusiform face area, occipital face area, and posterior superior temporal sulcus were selected as seeds for seed-based functional connectivity analyses. The interaction between early and recent stress was related to alterations during the processing of emotional expressions mainly in to the cerebellum, middle temporal gyrus, and supramarginal gyrus. For cumulative stress levels, such alterations were observed in functional connectivity to the middle temporal gyrus, lateral occipital cortex, precuneus, precentral and postcentral gyri, anterior and posterior cingulate gyri, and Heschl's gyrus. This study adds to the growing body of literature suggesting that both the cumulative and the match/mismatch hypotheses are useful in explaining the effects of stress.

The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders.

This study had three objectives: (1) to assess the relationship between the single nucleotide polymorphism (SNP) rs1789891 in the alcohol dehydrogenase gene cluster and alcohol dependence and affective disorders; (2) to assess the differences in the Regulative Theory of Temperament (RTT) traits between an alcohol dependent group, an affective disorders group, and a healthy group; and (3) to assess the relationship between rs1789891 and temperament traits in a healthy group, taking into account the interaction of genotype and sex. The SNP rs1789891 was genotyped in a group of 194 alcohol dependent men, aged 21 to 71 years; 137 patients with affective disorders, including 51 males and 86 females, aged 19 to 85 years; and a group of 207 healthy individuals, including 89 males and 118 females, aged 18 to 71 years. Temperament traits (briskness, perseveration, sensory sensitivity, emotional reactivity, endurance, and activity) were assessed in all groups using the Formal Characteristics of Behaviour-Temperament Inventory. The comparative analysis of genotypic frequencies showed no significant differences between patients with alcoholism or affective disorders and those in the control group. Alcohol dependent men and the affective disorder group were characterised by higher levels of emotional reactivity (p-value 1.4e-5 and 9.84e-7, respectively) and lower levels of briskness, sensory sensitivity, endurance, and activity (p-value from 3.76e-8 to 0.012) when compared to the healthy group. The rs1789891 polymorphism was associated with briskness (p = 0.02), sensory sensitivity (p = 0.036), and activity (p = 0.049). None of the results were statistically significant after Bonferroni correction.

[Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits]. / Polimorfizmy w genach systemu dopaminergicznego a cechy temperamentu EAS - rodzinne badanie asocjacyjne.

AIM: The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2, DRD3, DRD4, SNAP-25, ANKKland DATI) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used. METHOD: The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire. RESULTS: Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified. CONCLUSION: The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.

Association between temperament in terms of the Regulative Theory of Temperament and DRD4 and DAT1 gene polymorphisms.

OBJECTIVES: This is a study of the association between DRD4 exon III VNTR and DAT1 3'-untranslated region polymorphisms on the one hand and temperament assessed with the Formal Characteristics of Behaviour-Temperament Inventory on the other hand. METHODS: The study was run on 418 participants (314 women and 104 men) aged 18 to 55 years sampled from healthy male and female volunteers recruited from inhabitants of the Warsaw metropolis. RESULTS: Main effects of sex were found for briskness (F(1,417) = 9.05, P = .003, η(2) = 0.022), perseveration (F(1,417) = 37.83, P < .001, η(2) = 0.085), sensory sensitivity (F(1,417) = 14.16, P < .001, η(2) = 0.003), and emotional reactivity (F(1,417) = 34.67, P < .001, η(2) = 0.078). A significant main effect of DAT1 variant was also found for sensory sensitivity (F(1,417) = 7.36, P = .007, η(2) = 0.018). No main effects of DRD4 on any of the analyzed temperament traits were found. A significant interaction of sex and DRD4 variant was found for sensory sensitivity (F(1,417) = 5.68, P = .018, η(2) = 0.014). No significant 3-way interactions (DAT1 × DRD4 × sex) were found. CONCLUSIONS: A significant main effect of DAT1 polymorphism on sensory sensitivity and a significant interactive sex/DRD4 effect on that same trait were found.

[Psychometric properties of the Polish version of the Metacognitions Questionnaire-30]. / Wlasciwosci psychometryczne polskiej wersji The Metacognitions Questionnaire-30.

AIM: The aim of the present study was to examine basic psychometric properties as well as to confirm the five-factor structure of the Polish version ofthe Metacognitions Questionnaire-30 (MCQ-30), a short instrument to measure various aspects of maladaptive metacognitions. METHOD: The sample consisted of 315 individuals (239 females and 76 males). Fourty-five of the participants were examined twice within the test-retest procedure. Among questionnaires used in the study were MCQ-30, the State-Trait Anxiety Inventory (STAI) and four subscales chosen from the Neurotic Personality Questionnaire (KON-2006). RESULTS: Cronbach alphas, coefficients ofreliability, reached acceptable values (0.70-0.87). Correlation coefficient (Pearson's r) between two separate administrations ofMCQ-30 was high (0.72). Correlation coefficients between results of the MCQ-30 and results of the STAI and the part of KON-2006 were statistically significant and positive (018-064). Confirmatory factor analysis confirmed the five-factor structure of the questionnaire (the model was modified, and the method of maximum likelihood along with bootstrap procedure was used; goodness-of-fit indices were e.g. Chi2 [391] = 764.50 with p < 0.001, Chi2/df = 1.95, GFI = 0.858, RMSEA = 0.055). CONCLUSIONS: The results from this study show generally good psychometric properties of the Polish version of the metacognitions questionnaire. Polish version of the MCQ-30 seems to be a measure comparable with the original version.

Male sexual orientation, gender nonconformity, and neural activity during mental rotations: an fMRI study.

The cross-sex shift hypothesis predicts that gay men should perform more like heterosexual women on important neurocognitive tasks on which men score higher than women, such as mental rotation. Studies also suggest sex differences exist in the neural correlates of mental rotation. However, no studies have taken sexual orientation into account or considered within-group variation attributable to recalled gender nonconformity (a developmental trait reliably associated with human nonheterosexuality). We quantified the neural correlates of mental rotation by comparing two groups of gay men, gender conforming (n = 23) and gender nonconforming (n = 23), to gender conforming heterosexual men (n = 22) and women (n = 22). We observed a sex difference between heterosexual men and women in the premotor cortex/supplementary motor cortex and left medial superior frontal gyrus. We also observed a sex difference as well as a cross-sex shift in gay men who recalled being gender nonconforming as children in the right superior frontal gyrus, right angular gyrus, right amygdala/parahippocampal gyrus, and bilaterally in the middle temporal gyrus and precuneus. Thus, cross-sex shifts may be associated with underlying developmental factors which are associated with sexual orientation (such as gender nonconformity). The results also suggest that gay men should not be studied as a homogenous group.

Individual and Environmental Predictors of Age of First Intercourse and Number of Children by Age 27.

Reproductive behavior characteristics may be influenced by both social and individual factors. Recent studies have revealed that personality traits might be related to reproductive characteristics in adulthood. Little is known about potential mediators or moderators of relations between personality and reproductive behavior. The present study examines the relation between personality traits measured in early adolescence and the number of children people have by age 27, with an attempt to identify moderation and mediation effects. We used data from the longitudinal cohort (N = 585) collected as a part of the Child Development Project. Personality was measured with the use of Lanthier's Big Five Personality Questionnaire. Results from regression analyses and structural equation models showed that four of the five personality traits (except extraversion) were related to the number of children individuals had by age 27, and these associations were mediated by the age of first intercourse and participants' familial and educational plans. We also identified moderation effects of IQ and SES both on the associations of personality traits with mediators and the number of children by age 27.

Roles of Impulsivity, Motivation, and Emotion Regulation in Procrastination - Path Analysis and Comparison Between Students and Non-students.

Procrastination - an irrational delay of intended actions despite expecting to be worse off - is a complex and non-homogenous phenomenon. Previous studies have found a number of correlates of procrastination, some of which seem to be particularly important. Impulsivity is closely connected to procrastination on behavioral, genetic, and neuronal levels. Difficulties in emotion regulation have also been shown to be strongly related to procrastination. Procrastination can also be considered as a motivation-based problem. To try to disentangle the connections of impulsivity, emotion regulation, and motivation to procrastination we collected data from over 600 subjects using multiple questionnaires (PPS - Pure Procrastination Scale; UPPSP - Impulsive Behavior Scale, ERQ - Emotion Regulation Questionnaire and MDT - Motivational Diagnostic Test). Structural equation modeling was performed to test several possible relationships between the measured variables. The effects of student status and age have also been investigated. The final path model was a directional model based on six explanatory variables and accounted for 70% of the variance in procrastination. Path analysis revealed that the strongest contributions to procrastination came from lack of value, delay discounting, and lack of perseverance, suggesting the involvement of motivation and impulsivity. The model also revealed the moderating role of expressive suppression between several aspects of impulsivity and procrastination. Close inspection of the paths' weights suggests that there may be two partly competing strategies for dealing with impulsivity and negative emotions: either to suppress emotions and impulsive reactions or to react impulsively, discarding previous plans, and to procrastinate. Path invariance analysis showed the significant moderating roles of student status and age. Both in non-students and high-age groups, the path leading from suppression to procrastination was insignificant. This suggests that caution should be used in generalizing the results of studies carried out on students. These results support previous findings that procrastination may serve as a short-term mood regulation strategy. However, as the spectrum of the emotion regulation strategies included in the study was very limited, we conclude that future studies should seek more insight into the relationship between emotion regulation, self-control, and procrastination.

New Empirical Evidence on the Validity and the Reliability of the Early Life Stress Questionnaire in a Polish Sample.

Background: The Early Life Stress Questionnaire (ELSQ) is widely used to estimate the prevalence of negative events during childhood, including emotional, physical, verbal, sexual abuse, negligence, severe conflicts, separation, parental divorce, substance abuse, poverty, and so forth. Objective: This study presents the psychometric properties of the Polish adaptation of the ELSQ. It also verifies if early life stress (ELS) is a good predictor of psychopathology symptoms during adulthood. Materials and Methods: We analyzed data from two samples. Sample 1 was selected by random quota method from across the country and included 609 participants aged 18-50 years, 306 women (50.2%) and 303 men (49.8%). Sample 2 contained 503 young adults (253 women and 250 men) aged 18-25. Confirmatory and exploratory factor analyses were used to measure ELSQ internal consistency. The validity was based on the relation to psychopathological symptoms and substance misuse. Results: Results showed good internal consistency and validity. Exploratory factor analysis indicates a six-factor structure of the ELSQ. ELS was related to psychopathology in adulthood, including depressive, sociophobic, vegetative as well as pain symptoms. ELSQ score correlated also with alcohol use, but not nicotine dependence. Moreover, ELS was correlated with stress in adulthood. Conclusion: The findings indicate that the Polish version of the ELSQ is a valid and reliable instrument for assessing ELS in the Polish population and may be applied in both clinical and community samples.

East-West, Collectivist-Individualist: A Cross-Cultural Examination of Temperament in Toddlers from Chile, Poland, South Korea, and the U.S.

The present study examined toddler temperament across Chilean, South Korean, Polish, and US samples, providing an opportunity to examine both collectivist-individualist and East-West contrasts. The effect of culture on the three factor and 18 dimension scores provided by the Early Childhood Behavior Questionnaire were investigated. Results provide evidence of cross-cultural differences between the four samples. Chilean toddlers scored significantly higher than US, Polish, and South Korean children on the overall factor of Negative Affectivity, as well as higher than the Polish and South Korean samples on the Surgency factor. South Korean toddlers scored significantly higher on the factor of Effortful Control, and two related dimensions, than US, Polish, or Chilean samples. Results are discussed in terms of the apparent roles of individualism/collectivism and East-West distinctions in shaping temperament development.

Association between dopamine D4 receptor exon III polymorphism and emotional reactivity as a temperamental trait.

The association between high and low levels of emotional reactivity (ER) as a temperamental trait and the dopamine D4 receptor (DRD4) exon III polymorphism in healthy men aged 18 to 27 (M = 21.03, SD = 2.23) was examined. ER, measured by the Formal Characteristics of Behavior-Temperament Inventory (FCB-TI), is defined as a tendency to react intensively to emotion-generating stimuli and is expressed in high emotional sensitivity and in low emotional endurance. Data analysis demonstrated a statistically significant difference in the distribution of genotypic frequencies between the low and high ER groups: chi2 = 4.88; df = 1; p = .027, odds ratio (OR) =2.85, 95% confidence interval (CI) = 1.11-7.32. An insignificant difference in allele frequencies between the two groups was noted: chi(2) = 7.47; df = 3; p = .058; OR = 2.9, 95% CI = 1.29-6.53. These findings suggest a role of the DRD4 exon III polymorphism in the modulation of ER as a temperamental trait. Due to the preliminary nature of our findings, replication is necessary.

Erotic subset for the Nencki Affective Picture System (NAPS ERO): cross-sexual comparison study.

Research on the processing of sexual stimuli has proved that such material has high priority in human cognition. Yet, although sex differences in response to sexual stimuli were extensively discussed in the literature, sexual orientation was given relatively little consideration, and material suitable for relevant research is difficult to come by. With this in mind, we present a collection of 200 erotic images, accompanied by their self-report ratings of emotional valence and arousal by homo- and heterosexual males and females (n = 80, divided into four equal-sized subsamples). The collection complements the Nencki Affective Picture System (NAPS) and is intended to be used as stimulus material in experimental research. The erotic images are divided into five categories, depending on their content: opposite-sex couple (50), male couple (50), female couple (50), male (25) and female (25). Additional 100 control images from the NAPS depicting people in a non-erotic context were also used in the study. We showed that recipient sex and sexual orientation strongly influenced the evaluation of erotic content. Thus, comparisons of valence and arousal ratings in different subject groups will help researchers select stimuli set for the purpose of various experimental designs. To facilitate the use of the dataset, we provide an on-line tool, which allows the user to browse the images interactively and select proper stimuli on the basis of several parameters. The NAPS ERO image collection together with the data are available to the scientific community for non-commercial use at http://naps.nencki.gov.pl.

On the relationship between temperament, metacognition, and anxiety: independent and mediated effects.

The present study examined the relations between temperamental traits distinguished in regulative theory of temperament, state anxiety, and metacognition as postulated in self-regulatory executive function (S-REF) theory of emotional disorder. Data analysis (n=315) consisted of independent and mediated effect analyses. Of the six traits, briskness, emotional reactivity and perseveration correlated significantly with both state anxiety and metacognitions (emotional reactivity and perseveration correlated positively, and briskness - negatively). These traits were predictors of state anxiety. Metacognition predicted state anxiety and relationships were independent of temperament. A mediating effect of metacognition was confirmed for the general index as well as negative and positive belief subscales. The findings support the metacognitive model of psychopathology and suggest that temperament is associated with metacognitions implicated in psychopathology and may have both direct and metacognitively mediated effects on anxiety.

The validation of the Polish version of the Posttraumatic Diagnostic Scale and its factor structure.

BACKGROUND: Posttraumatic Diagnostic Scale (PDS) is a self-descriptive measure developed to provide information regarding posttraumatic stress disorder (PTSD) diagnosis and symptom severity. OBJECTIVES: THE AIM OF THIS ARTICLE IS TO REPORT ON THE VALIDATION OF THE POLISH VERSION OF PDS AND TO TEST ITS FACTOR STRUCTURE WITH REFERENCE TO TWO MODELS: an original three-factor model (Reexperiencing, Avoidance, and Arousal) and alternative five-factor model (Reexperiencing, Avoidance, Numbing, Dysphoric Arousal, and Anxious Arousal). METHOD: THE VALIDATION PROCEDURE INCLUDED THREE STUDIES CONDUCTED ON SAMPLES OF SEPARATE POPULATIONS: university-level students (n=507), individuals who had experienced various traumas (n=320), and treatment-seeking survivors of motor vehicle accidents (MVA) (n=302). Various other measures of trauma-related psychopathology were administered to participants, as well as the PTSD module of the Structured Clinical Interview (SCID) in the case of MVA patients. RESULTS: PDS showed high internal consistency and test-retest reliability, good diagnostic agreement with SCID, good sensitivity but relatively low specificity. The satisfactory convergent validity was supported by a large number of significant correlations with other measures of trauma-related psychopathology. Confirmatory factor analysis (CFA) generally confirmed both the three-factor structure and the alternative five-factor structure of the questionnaire. CONCLUSIONS: The results show generally good psychometric properties of the Polish version of PDS.

The association between dopamine D4 receptor exon III polymorphism and intensity of PTSD symptoms among flood survivors.

Thanks to the development of molecular genetics methods it is now possible to look for the genes which may contribute to posttraumatic stress disorder (PTSD). Polymorphism located in exon III of dopamine receptor type 4 (DRD4) gene was related to maladaptive stress responses as well as temperament traits related to PTSD. This study analyzed the association between the variable number tandem repeat (VNTR) DRD4 exon III polymorphism and intensity of PTSD symptoms in 107 (57 women and 50 men) survivors of a flood aged 14-62. Intensity of PTSD symptoms was measured using PTSD-F and PTSD-C questionnaires. Multivariate analysis of covariance (MANCOVA) was conducted to test the main and interactive effects of genotype and level of trauma exposure. Participants with at least one copy of the DRD4 long allele (seven or eight repetitions) had more intense PTSD symptoms on the Avoidance/Numbing scale (Cohen's f = .22) and the Total Scale (Cohen's f = .2) of the PTSD-F than participants who did not have these alleles in genotype. The results must be treated with caution, however, due to methodological restrictions and they need to be replicated on a larger sample.

Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population.

The aim of our study was to determine whether the 5-HTTLPR polymorphism is related to temperamental traits measured using the Formal Characteristics of Behavior - Temperament Inventory (FCB-TI) and personality traits assessed by the NEO Five-Factor Inventory (NEO-FFI) questionnaire. The sample comprised 200 unrelated females, aged 18-29 years. DNA of the subjects was isolated from buccal epithelial cells, and 5-HTTLPR polymorphism was genotyped using PCR. The subjects were divided into SS, SL and LL groups according to their genotype. The differences in results on the endurance scale (F = 11.29, p = 0.001), measured using FCB-TI and neuroticism measured using NEO-FFI (F = 15.32, p = 0.000) between the S group (short-form allele; genotypes SS and SL) and the L group (long-form allele; genotype LL) were statistically significant. Additionally, statistically significant differences between the LL and SS groups, and between the SL and SS groups with respect to 'activity' (FCB-TI) were found (F = 4.5, p = 0.012). These findings support a role of the 5-HTTLPR polymorphism in the modulation of personality and temperamental traits.

Polymorphisms in the serotonin transporter gene and their relationship to two temperamental traits measured by the formal characteristics of behavior-temperament inventory: activity and emotional reactivity.

Results obtained in earlier studies indicate that 5-HTT gene polymorphisms may have a certain impact on individual differences with respect to temperamental traits. The aim of our study was to determine whether the occurrence of various alleles of the serotonin transporter gene is related to the variability of two temperamental traits postulated in the Regulative Theory of Temperament (RTT)--activity and emotional reactivity. We have demonstrated that the 5-HTTLPR polymorphism is associated with one of the RTT temperamental traits--activity. Neither the relationship between the regulatory region polymorphism and emotional reactivity nor the association between the intron 2 VNTR polymorphism and the temperamental traits under study has been confirmed.