Detalhe da pesquisa
1.
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nat Chem Biol
; 17(9): 954-963, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972797
2.
Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome.
Chembiochem
; 18(6): 523-526, 2017 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28098422
3.
Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.
Angew Chem Int Ed Engl
; 55(42): 13330-13334, 2016 10 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27709817
4.
Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome.
J Am Chem Soc
; 137(25): 8121-30, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26050527
5.
Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine.
Angew Chem Int Ed Engl
; 54(52): 15888-91, 2015 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26563572
6.
Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif.
Angew Chem Int Ed Engl
; 53(6): 1679-83, 2014 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24403024
7.
Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew Chem Int Ed Engl
; 53(44): 11969-73, 2014 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25244435
8.
Covalent and non-covalent reversible proteasome inhibition.
Biol Chem
; 393(10): 1101-20, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23091276
9.
Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries.
J Med Chem
; 65(15): 10341-10356, 2022 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35912476
10.
A mass spectrometry platform for a streamlined investigation of proteasome integrity, posttranslational modifications, and inhibitor binding.
Chem Biol
; 22(3): 404-11, 2015 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728267