Detalhe da pesquisa
1.
RyR2 C-terminal truncating variants identified in patients with arrhythmic phenotypes exert a dominant negative effect through formation of wildtype-truncation heteromers.
Biochem J
; 480(17): 1379-1395, 2023 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37492947
2.
Selectivity filter modalities and rapid inactivation of the hERG1 channel.
Proc Natl Acad Sci U S A
; 117(6): 2795-2804, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31980532
3.
The voltage-sensing domain of a hERG1 mutant is a cation-selective channel.
Biophys J
; 121(23): 4585-4599, 2022 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36815709
4.
Short-coupled ventricular fibrillation represents a distinct phenotype among latent causes of unexplained cardiac arrest: a report from the CASPER registry.
Eur Heart J
; 42(29): 2827-2838, 2021 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34010395
5.
Refinement of a cryo-EM structure of hERG: Bridging structure and function.
Biophys J
; 120(4): 738-748, 2021 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33476597
6.
An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition.
Circulation
; 141(6): 429-439, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31941373
7.
Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach.
J Chem Inf Model
; 61(9): 4266-4279, 2021 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34420294
8.
The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.
Mol Pharmacol
; 96(2): 259-271, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182542
9.
A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources.
J Physiol
; 597(17): 4533-4564, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31278749
10.
Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.
J Am Soc Nephrol
; 29(4): 1165-1181, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29439156
11.
Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts.
Biochem J
; 473(21): 3951-3964, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27582498
12.
Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.
Biophys J
; 108(6): 1414-1424, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809254
13.
NS1643 interacts around L529 of hERG to alter voltage sensor movement on the path to activation.
Biophys J
; 108(6): 1400-1413, 2015 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25809253
14.
Ivabradine prolongs phase 3 of cardiac repolarization and blocks the hERG1 (KCNH2) current over a concentration-range overlapping with that required to block HCN4.
J Mol Cell Cardiol
; 85: 71-8, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25986146
15.
Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.
J Biol Chem
; 289(28): 19571-84, 2014 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24841199
16.
Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.
Am J Physiol Heart Circ Physiol
; 308(12): H1564-74, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25862829
17.
Phospholamban knockout breaks arrhythmogenic Ca²âº waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice.
Circ Res
; 113(5): 517-26, 2013 Aug 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856523
18.
Inflammasome-independent NLRP3 augments TGF-ß signaling in kidney epithelium.
J Immunol
; 190(3): 1239-49, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23264657
19.
The Alberta Heart Failure Etiology and Analysis Research Team (HEART) study.
BMC Cardiovasc Disord
; 14: 91, 2014 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25063541
20.
Series of (([1,1'-Biphenyl]-2-yl)methyl)sulfinylalkyl Alicyclic Amines as Novel and High Affinity Atypical Dopamine Transporter Inhibitors with Reduced hERG Activity.
ACS Pharmacol Transl Sci
; 7(2): 515-532, 2024 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38357284