Detalhe da pesquisa
1.
Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO).
Bioorg Med Chem Lett
; 42: 128010, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33811992
2.
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase.
Bioorg Med Chem
; 28(22): 115723, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007547
3.
Pharmacologic profile of the Adnectin BMS-962476, a small protein biologic alternative to PCSK9 antibodies for low-density lipoprotein lowering.
J Pharmacol Exp Ther
; 350(2): 412-24, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24917546
4.
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg Med Chem Lett
; 23(14): 4107-11, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23747226
5.
Structural basis for CARM1 inhibition by indole and pyrazole inhibitors.
Biochem J
; 436(2): 331-9, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21410432
6.
Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events.
J Biol Chem
; 285(52): 40965-78, 2010 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-20937814
7.
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Anal Biochem
; 392(1): 59-69, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19497292
8.
Synthesis and SAR of new pyrrolo[2,1-f][1,2,4]triazines as potent p38 alpha MAP kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2739-44, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18364256
9.
Triazolopyrimidines identified as reversible myeloperoxidase inhibitors.
Medchemcomm
; 8(11): 2093-2099, 2017 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108726
10.
Structural basis for the high-affinity binding of pyrrolotriazine inhibitors of p38 MAP kinase.
Acta Crystallogr D Biol Crystallogr
; D64(Pt 7): 705-10, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566506
11.
Use of microcalorimetry and its correlation with size exclusion chromatography for rapid screening of the physical stability of large pharmaceutical proteins in solution.
Pharm Dev Technol
; 12(3): 265-73, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17613890