Detalhe da pesquisa
1.
Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases.
J Med Chem
; 67(7): 5233-5258, 2024 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38552030
2.
IRAK4 inhibition dampens pathogenic processes driving inflammatory skin diseases.
Sci Transl Med
; 15(683): eabj3289, 2023 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36791209
3.
Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS-5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip.
Clin Pharmacol Drug Dev
; 11(1): 112-122, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34859612
4.
GLPG1205, a GPR84 Modulator: Safety, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects.
Clin Pharmacol Drug Dev
; 10(9): 994-1006, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33960725
5.
Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
J Med Chem
; 63(22): 13526-13545, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902984
6.
Safety, Pharmacokinetics, and Pharmacodynamics of the Autotaxin Inhibitor GLPG1690 in Healthy Subjects: Phase 1 Randomized Trials.
J Clin Pharmacol
; 59(10): 1366-1378, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31012984
7.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial.
Lancet Respir Med
; 6(8): 627-635, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29792287
8.
Neutralization of IL-17C Reduces Skin Inflammation in Mouse Models of Psoriasis and Atopic Dermatitis.
J Invest Dermatol
; 138(7): 1555-1563, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29474945
9.
Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury.
Circ Res
; 90(10): 1087-92, 2002 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-12039798
10.
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
J Med Chem
; 57(23): 10044-57, 2014 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25380412
11.
Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta.
Dev Dyn
; 226(1): 103-6, 2003 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-12508230
12.
Estradiol enhances primary antigen-specific CD4 T cell responses and Th1 development in vivo. Essential role of estrogen receptor alpha expression in hematopoietic cells.
Eur J Immunol
; 33(2): 512-21, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12645950
13.
Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol.
Proc Natl Acad Sci U S A
; 100(16): 9614-9, 2003 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12878732