Detalhe da pesquisa
1.
Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol.
Environ Sci Technol
; 58(16): 6913-6923, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593436
2.
Measurement-Based Domain Parameter Optimization in Electrical Impedance Tomography Imaging.
Sensors (Basel)
; 21(7)2021 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33916751
3.
Effect of Endocannabinoid Oleamide on Rat and Human Liver Cytochrome P450 Enzymes in In Vitro and In Vivo Models.
Drug Metab Dispos
; 46(6): 913-923, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29650790
4.
Comparison of HepaRG and HepG2 cell lines to model mitochondrial respiratory adaptations in nonalcoholic fatty liver disease.
Int J Mol Med
; 53(2)2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38186319
5.
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway.
J Med Chem
; 67(1): 81-109, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38157261
6.
Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2-a]pyridine Structure.
J Med Chem
; 66(4): 2422-2456, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36756805
7.
Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis.
Toxicol Sci
; 196(2): 200-217, 2023 11 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37632784
8.
2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR).
Eur J Med Chem
; 259: 115631, 2023 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473690
9.
Real-time monitoring of Metridia luciferase release from cells upon interaction with model toxic substances by a fully automatic flow setup - A proof of concept.
Talanta
; 245: 123465, 2022 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35427949
10.
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes.
Mol Nutr Food Res
; 66(9): e2200070, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35184385
11.
Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain.
Cells
; 9(12)2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33255185
12.
The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids.
Acta Pharm Sin B
; 10(1): 136-152, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31998607
13.
Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors.
Toxicol Lett
; 300: 81-91, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-30394306
14.
Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver.
Toxicol Lett
; 313: 1-10, 2019 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31170421
15.
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-ß-d-ribofuranose 2'-Oxidase.
J Med Chem
; 62(17): 8115-8139, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31393122
16.
Teriflunomide Is an Indirect Human Constitutive Androstane Receptor (CAR) Activator Interacting With Epidermal Growth Factor (EGF) Signaling.
Front Pharmacol
; 9: 993, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30364229
17.
Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.
Food Chem Toxicol
; 109(Pt 1): 130-142, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28887089
18.
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine.
Eur J Med Chem
; 135: 142-158, 2017 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28441582
19.
Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor.
Toxicol Lett
; 265: 86-96, 2017 Jan 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27871908
20.
Synthesis of novel amphiphilic hyaluronan containing-aromatic fatty acids for fabrication of polymeric micelles.
Carbohydr Polym
; 151: 1175-1183, 2016 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27474668