Detalhe da pesquisa
1.
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate.
Bioorg Med Chem Lett
; 31: 127669, 2021 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33171218
2.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem
; 66(4): 2877-2892, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757100
3.
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.
Bioorg Med Chem Lett
; 21(1): 42-4, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21159507
4.
The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor.
Bioorg Med Chem Lett
; 21(18): 5552-6, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21802951
5.
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
ACS Med Chem Lett
; 11(10): 2002-2009, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062185
6.
Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.
J Pharmacol Exp Ther
; 330(1): 142-51, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19363060
7.
Novel imidazole-based histamine H3 antagonists.
Bioorg Med Chem Lett
; 19(3): 903-7, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19119007
8.
2-Alkyl-4-aryl-pyrimidine fused heterocycles as selective 5-HT2A antagonists.
Bioorg Med Chem Lett
; 18(6): 2103-8, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18282705
9.
A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
J Med Chem
; 61(1): 207-223, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29211470
10.
4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
J Med Chem
; 60(11): 4559-4572, 2017 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28493698
11.
Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform.
J Biomol Screen
; 21(2): 127-35, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26442913
12.
4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists.
J Med Chem
; 48(6): 2229-38, 2005 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15771465
13.
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
J Med Chem
; 48(26): 8289-98, 2005 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-16366610
14.
Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.
ACS Med Chem Lett
; 6(9): 1015-8, 2015 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26396690
15.
A new class of diamine-based human histamine H3 receptor antagonists: 4-(aminoalkoxy)benzylamines.
J Med Chem
; 46(18): 3938-44, 2003 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-12930154
16.
The first potent and selective non-imidazole human histamine H4 receptor antagonists.
J Med Chem
; 46(19): 3957-60, 2003 Sep 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12954048
17.
Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects.
ACS Med Chem Lett
; 3(8): 637-9, 2012 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900524
18.
Recent medicinal chemistry of the histamine H3 receptor.
Prog Med Chem
; 44: 181-206, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16697898
19.
Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines.
Eur J Med Chem
; 44(10): 4098-106, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19524331
20.
Palladium-catalyzed coupling of pyrazole triflates with arylboronic acids.
J Org Chem
; 70(10): 4188-90, 2005 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15876117