[The specific features of copper and manganese metabolism in the use of iron-containing preparations].

AIM: To comparatively evaluate the efficiency of preventive treatment with various iron preparations on copper, manganese, and iron metabolic features in adult athletes. SUBJECTS AND METHODS: Forty adult highly qualified sambo wrestlers were examined and divided into 4 groups of 10 persons in each. Group 1 athletes took iron-containing Sorbifer Durules in combination with ascorbic acid; Group 2 received Ferro Gradumet Vitamin C; Group 3 had Hemofer and ascorbic acid; Group 4 took ascorbic acid tablets. The latter group served as a control. Blood samples (15-20 ml) to be tested were taken at the beginning and end of 2-week use of iron preparations. The daily balance of iron, copper, and manganese was estimated following 7-day intake of these preparations. RESULTS: The use of iron-containing preparations in combination with ascorbic acid was ascertained to be accompanied by an increment in the plasma concentration of iron and blood corpuscles, indicating an increased need for this biotic and its deficiency in athletes. When the dose of iron was increased in the iron preparations, there was a substantial rise in the excretion of copper, manganese in particular, through the gastrointestinal tract and kidney and a negative balance of these trace elements in the body. CONCLUSION: Dietary addition of foods containing large amounts of ferrous iron, copper, and manganese is indicated for athletes exposed to higher intensity exercises.

[Effect of vitamin supplementation on the metabolism of iron, copper and manganese in athletes]. / Vliianie priëma vitaminov na obmen zheleza, medi i margantsa v organizme sportsmenov.

The intake of vitamins C, P or vitamin complex (ascorutine, thiamine, riboflavine, pyridoxine, cyan cobalamin, folic acid) influenced direct and indirect indexes of iron, copper, and manganese metabolism increasing excretion of these biotics through intestinal tract and kidneys of sportsmen skiers. Addition of vitamin complex with trace elements and macroelements to the ration improved iron and copper balance in the body and functional status of athletes better than vitamins alone.

[The causes, diagnosis and treatment of iron-deficiency states in the population (a review)]. / Prichiny, diagnostika i lechenie zhelezodefitsitnykh sostoianii naseleniia (obzor).

Investigation has indicated that the main cause of blood iron deficiency is insufficient dietary intake of iron, vitamins, and proteins. The comprehensive examination of all iron metabolism-associated indices may identify iron deficiency, hematological parameteres being much more preferred. Iron drugs in combination with other trace elements, vitamins, and amino acids should be prescribed in this abnormality.