Detalhe da pesquisa
1.
Comparative Impact of Various Fasting Periods on the Welfare of Sprague-Dawley Rats With or Without Supplementation.
Toxicol Pathol
; 52(1): 21-34, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38379371
2.
Reduced Fasting Duration in Cynomolgus Monkeys Enhances Animal Welfare During Toxicology Studies.
Toxicol Pathol
; 51(5): 264-277, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37702042
3.
Toxicologic Pathology Forum Opinion Piece: Use of Virtual Control Groups in Nonclinical Toxicity Studies: The Anatomic Pathology Perspective.
Toxicol Pathol
; 51(6): 390-396, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38293937
4.
Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach.
Regul Toxicol Pharmacol
; 138: 105329, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36592682
5.
The use of recovery animals in nonclinical safety assessment studies with monoclonal antibodies: further 3Rs opportunities remain.
Regul Toxicol Pharmacol
; 138: 105339, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36649820
6.
Trastuzumab does not bind rat or mouse ErbB2/neu: implications for selection of non-clinical safety models for trastuzumab-based therapeutics.
Breast Cancer Res Treat
; 191(2): 303-317, 2022 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-34708303
7.
Ovarian Toxicity Assessment in Histopathological Images Using Deep Learning.
Toxicol Pathol
; 48(2): 350-361, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31594487
8.
Scientific and Regulatory Policy Committee Points to Consider*: The Toxicologic Pathologist's Role in the 3Rs.
Toxicol Pathol
; 47(7): 789-798, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31648619
9.
Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.
Regul Toxicol Pharmacol
; 92: 382-389, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29278695
10.
A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 1 of 2).
Toxicol Pathol
; 45(8): 1043-1054, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29173114
11.
A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2).
Toxicol Pathol
; 45(8): 1055-1066, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29233079
12.
Preclinical safety profile of trastuzumab emtansine (T-DM1): mechanism of action of its cytotoxic component retained with improved tolerability.
Toxicol Appl Pharmacol
; 273(2): 298-313, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035823
13.
Fostering Animal Welfare and Advancing 3Rs Principles through the Establishment of a 3Rs Advisory Group.
Animals (Basel)
; 13(24)2023 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38136900
14.
Equine Gunshot Euthanasia: Creation of a 3D-Printed Model with Integrated Sensors for Training.
Animals (Basel)
; 13(16)2023 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37627357
15.
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
J Pharmacol Toxicol Methods
; 121: 107266, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36963703
16.
Phase I/II Trial of Vemurafenib in Dogs with Naturally Occurring, BRAF-mutated Urothelial Carcinoma.
Mol Cancer Ther
; 20(11): 2177-2188, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34433660
17.
Toxicopathology of the developing immune system: investigative and development strategies.
Toxicol Pathol
; 38(7): 1111-7, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20962107
18.
Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody.
JCI Insight
; 5(7)2020 04 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32271166
19.
Placental and Fetal Effects of Onartuzumab, a Met/HGF Signaling Antagonist, When Administered to Pregnant Cynomolgus Monkeys.
Toxicol Sci
; 165(1): 186-197, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29893934
20.
Tissue Physiology of Cynomolgus Monkeys: Cross-Species Comparison and Implications for Translational Pharmacology.
AAPS J
; 20(6): 107, 2018 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30298434