Detalhe da pesquisa
1.
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).
Bioorg Med Chem Lett
; 28(1): 6-10, 2018 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29169674
2.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(10): 6271-80, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27503647
3.
Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide.
Bioorg Med Chem Lett
; 26(13): 3182-3186, 2016 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27210432
4.
Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide.
Bioorg Med Chem Lett
; 25(23): 5589-93, 2015 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26508546
5.
Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
Bioorg Med Chem Lett
; 22(3): 1299-307, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22243961
6.
Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.
Bioorg Med Chem Lett
; 21(2): 644-51, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21195617
7.
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation.
mBio
; 11(1)2020 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992618
8.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs.
ACS Infect Dis
; 6(2): 180-185, 2020 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31876143
9.
Macrofilaricidal Benzimidazole-Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs.
ACS Infect Dis
; 6(2): 173-179, 2020 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31876154
10.
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.
J Med Chem
; 60(13): 5889-5908, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28635296
11.
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
J Med Chem
; 60(19): 8011-8026, 2017 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28953378
12.
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.
J Med Chem
; 58(13): 5344-54, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26067904