Pesquisa | Biblioteca Virtual em Saúde

1.

Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial.

Zhu, Andrew X; Finn, Richard S; Edeline, Julien; Cattan, Stephane; Ogasawara, Sadahisa; Palmer, Daniel; Verslype, Chris; Zagonel, Vittorina; Fartoux, Laetitia; Vogel, Arndt; Sarker, Debashis; Verset, Gontran; Chan, Stephen L; Knox, Jennifer; Daniele, Bruno; Webber, Andrea L; Ebbinghaus, Scot W; Ma, Junshui; Siegel, Abby B; Cheng, Ann-Lii; Kudo, Masatoshi.

Lancet Oncol ; 19(7): 940-952, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29875066

2.

Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma.

Hamid, Omid; Robert, Caroline; Daud, Adil; Hodi, F Stephen; Hwu, Wen-Jen; Kefford, Richard; Wolchok, Jedd D; Hersey, Peter; Joseph, Richard W; Weber, Jeffrey S; Dronca, Roxana; Gangadhar, Tara C; Patnaik, Amita; Zarour, Hassane; Joshua, Anthony M; Gergich, Kevin; Elassaiss-Schaap, Jeroen; Algazi, Alain; Mateus, Christine; Boasberg, Peter; Tumeh, Paul C; Chmielowski, Bartosz; Ebbinghaus, Scot W; Li, Xiaoyun Nicole; Kang, S Peter; Ribas, Antoni.

N Engl J Med ; 369(2): 134-44, 2013 Jul 11.

Artigo em Inglês | MEDLINE | ID: mdl-23724846

3.

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial.

Robert, Caroline; Ribas, Antoni; Wolchok, Jedd D; Hodi, F Stephen; Hamid, Omid; Kefford, Richard; Weber, Jeffrey S; Joshua, Anthony M; Hwu, Wen-Jen; Gangadhar, Tara C; Patnaik, Amita; Dronca, Roxana; Zarour, Hassane; Joseph, Richard W; Boasberg, Peter; Chmielowski, Bartosz; Mateus, Christine; Postow, Michael A; Gergich, Kevin; Elassaiss-Schaap, Jeroen; Li, Xiaoyun Nicole; Iannone, Robert; Ebbinghaus, Scot W; Kang, S Peter; Daud, Adil.

Lancet ; 384(9948): 1109-17, 2014 Sep 20.

Artigo em Inglês | MEDLINE | ID: mdl-25034862

4.

Adjuvant Pembrolizumab versus IFNα2b or Ipilimumab in Resected High-Risk Melanoma.

Grossmann, Kenneth F; Othus, Megan; Patel, Sapna P; Tarhini, Ahmad A; Sondak, Vernon K; Knopp, Michael V; Petrella, Teresa M; Truong, Thach-Giao; Khushalani, Nikhil I; Cohen, Justine V; Buchbinder, Elizabeth I; Kendra, Kari; Funchain, Pauline; Lewis, Karl D; Conry, Robert M; Chmielowski, Bartosz; Kudchadkar, Ragini R; Johnson, Douglas B; Li, Hongli; Moon, James; Eroglu, Zeynep; Gastman, Brian; Kovacsovics-Bankowski, Magdalena; Gunturu, Krishna S; Ebbinghaus, Scot W; Ahsan, Sama; Ibrahim, Nageatte; Sharon, Elad; Korde, Larissa A; Kirkwood, John M; Ribas, Antoni.

Cancer Discov ; 12(3): 644-653, 2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-34764195

5.

Modernizing Clinical Trial Eligibility Criteria: Recommendations of the ASCO-Friends of Cancer Research Washout Period and Concomitant Medication Work Group.

Harvey, R Donald; Mileham, Kathryn F; Bhatnagar, Vishal; Brewer, Jamie R; Rahman, Atiqur; Moravek, Cassadie; Kennedy, Andrew S; Ness, Elizabeth A; Dees, E Claire; Ivy, S Percy; Ebbinghaus, Scot W; Schenkel, Caroline; Uldrick, Thomas S.

Clin Cancer Res ; 27(9): 2400-2407, 2021 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-33563635

6.

A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity.

Palumbo, SunMi L; Memmott, Regan M; Uribe, Diana J; Krotova-Khan, Yulia; Hurley, Laurence H; Ebbinghaus, Scot W.

Nucleic Acids Res ; 36(6): 1755-69, 2008 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-18252774

7.

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial.

Finn, Richard S; Ryoo, Baek-Yeol; Merle, Philippe; Kudo, Masatoshi; Bouattour, Mohamed; Lim, Ho Yeong; Breder, Valeriy; Edeline, Julien; Chao, Yee; Ogasawara, Sadahisa; Yau, Thomas; Garrido, Marcelo; Chan, Stephen L; Knox, Jennifer; Daniele, Bruno; Ebbinghaus, Scot W; Chen, Erluo; Siegel, Abby B; Zhu, Andrew X; Cheng, Ann-Lii.

J Clin Oncol ; 38(3): 193-202, 2020 01 20.

Artigo em Inglês | MEDLINE | ID: mdl-31790344

8.

Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.

Palumbo, SunMi L; Ebbinghaus, Scot W; Hurley, Laurence H.

J Am Chem Soc ; 131(31): 10878-91, 2009 Aug 12.

Artigo em Inglês | MEDLINE | ID: mdl-19601575

9.

Pembrolizumab Utilization and Outcomes for Advanced Melanoma in US Community Oncology Practices.

Cowey, C Lance; Liu, Frank Xiaoqing; Black-Shinn, Jenny; Stevinson, Kendall; Boyd, Marley; Frytak, Jennifer R; Ebbinghaus, Scot W.

J Immunother ; 41(2): 86-95, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-29252916

10.

Pembrolizumab Exposure-Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance.

Turner, David C; Kondic, Anna G; Anderson, Keaven M; Robinson, Andrew G; Garon, Edward B; Riess, Jonathan Wesley; Jain, Lokesh; Mayawala, Kapil; Kang, Jiannan; Ebbinghaus, Scot W; Sinha, Vikram; de Alwis, Dinesh P; Stone, Julie A.

Clin Cancer Res ; 24(23): 5841-5849, 2018 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-29891725

11.

Mechanism of PNA transport to the nuclear compartment.

Stankova, Lenka; Ziemba, Amy J; Zhilina, Zhanna V; Ebbinghaus, Scot W.

Ann N Y Acad Sci ; 1082: 27-30, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17145921

12.

Peptide nucleic acid conjugates: synthesis, properties and applications.

Zhilina, Zhanna V; Ziemba, Amy J; Ebbinghaus, Scot W.

Curr Top Med Chem ; 5(12): 1119-31, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-16248787

13.

Targeting and regulation of the HER-2/neu oncogene promoter with bis-peptide nucleic acids.

Ziemba, Amy J; Zhilina, Zhanna V; Krotova-Khan, Yulia; Stankova, Lenka; Ebbinghaus, Scot W.

Oligonucleotides ; 15(1): 36-50, 2005.

Artigo em Inglês | MEDLINE | ID: mdl-15788899

14.

Renal cell carcinoma: rationale and development of therapeutic inhibitors of angiogenesis.

Ebbinghaus, Scot W; Gordon, Michael S.

Hematol Oncol Clin North Am ; 18(5): 1143-59, ix-x, 2004 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15474339

15.

Tolerability, safety and pharmacokinetics of ridaforolimus in combination with bicalutamide in patients with asymptomatic, metastatic castration-resistant prostate cancer (CRPC).

Meulenbeld, Hielke J; de Bono, Johann S; Tagawa, Scott T; Whang, Young E; Li, Xiaoyun; Heath, Karl H; Zandvliet, Anthe S; Ebbinghaus, Scot W; Hudes, Gary R; de Wit, Ronald.

Cancer Chemother Pharmacol ; 72(4): 909-16, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-23921574

16.

Site-selective DNA binding drugs.

Ebbinghaus, Scot W.

Chem Biol ; 10(10): 895-7, 2003 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-14583253

17.

Voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedules.

Advani, Ranjana H; Hurwitz, Herbert I; Gordon, Michael S; Ebbinghaus, Scot W; Mendelson, David S; Wakelee, Heather A; Hoch, Ute; Silverman, Jeffrey A; Havrilla, Nancy A; Berman, Craig J; Fox, Judith A; Allen, Roberta S; Adelman, Daniel C.

Clin Cancer Res ; 16(7): 2167-75, 2010 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-20233886

18.

PNA-nitrogen mustard conjugates are effective suppressors of HER-2/neu and biological tools for recognition of PNA/DNA interactions.

Zhilina, Zhanna V; Ziemba, Amy J; Nielsen, Peter E; Ebbinghaus, Scot W.

Bioconjug Chem ; 17(1): 214-22, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16417271

19.

Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter.

De Armond, Richard; Wood, Stacey; Sun, Daekyu; Hurley, Laurence H; Ebbinghaus, Scot W.

Biochemistry ; 44(49): 16341-50, 2005 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-16331995

20.

A bis-alkylating triplex forming oligonucleotide inhibits intracellular reporter gene expression and prevents triplex unwinding due to helicase activity.

Ziemba, Amy J; Reed, Michael W; Raney, Kevin D; Byrd, Alicia B; Ebbinghaus, Scot W.

Biochemistry ; 42(17): 5013-24, 2003 May 06.

Artigo em Inglês | MEDLINE | ID: mdl-12718544

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